Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.

Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Research Abstract Details 

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Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Abstract Text:

Nobuko Ishiura,Manabu Fujimoto,Rei Watanabe,Hiroko Nakashima,Yoshihiro Kuwano,Norihito Yazawa,Takeshi Echigo,Hitoshi Okochi,Kunihiko Tamaki,Nobuko Ishiura,Manabu Fujimoto,Rei Watanabe,Hiroko Nakashima,Yoshihiro Kuwano,Norihito Yazawa,Takeshi Echigo,Hitoshi Okochi,Kunihiko Tamaki,

BACKGROUND: Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230. NC16A, a non-collagenous stretch of the BP180 ectodomain is the primary target of pathogenic IgG antibodies. Whereas IgG anti-BP180 autoantibodies play a primary role in the pathogenesis, there is a growing number of data regarding the potential pathogenic roles of IgE class autoantibodies in BP. OBJECTIVES: To examine the levels of IgG and IgE autoantibodies against BP180 and BP230, and to investigate mutual association and clinical relevance. METHODS: Sera obtained from 67BP patients and 36 healthy donors were subjected to ELISA assays to measure serum IgG and IgE levels of anti-BP180 and anti-BP230 antibodies. RESULTS: IgG anti-BP180 antibodies were positive in 63 (94%) of 67BP patients. IgG anti-BP230, IgE anti-BP180, and IgE anti-BP230 antibodies were found in 48 (72%), 20 (30%) and 45 (67%), respectively. IgG anti-BP180 levels were correlated with the affected areas. IgG anti-BP230 antibodies tended to increase in proportion to elongation of disease duration. IgE anti-BP230 levels showed a strong association with local eosinophil accumulation, while the levels were reversely related with the affected areas in BP. CONCLUSIONS: IgE autoantibodies to BP180 and BP230 are detected at high frequencies in BP. IgE anti-BP230 antibodies may have a role in attracting eosinophils to the skin lesions.

Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Publishing Authors By Initials

N Ishiura,M Fujimoto,R Watanabe,H Nakashima,Y Kuwano,N Yazawa,T Echigo,H Okochi,K Tamaki,N Ishiura,M Fujimoto,R Watanabe,H Nakashima,Y Kuwano,N Yazawa,T Echigo,H Okochi,K Tamaki,

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Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of dermatological science

VOLUME: 49

Page Numbers: 153-61

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ISSN: 0923-1811

DAY: 24

MONTH: 10

YEAR: 2007

Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Information

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LANGUAGE: eng

NlmUniqueID: 9011485

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Grant and Affiliation Information for Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.

AFFILIATION: Department of Dermatology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.

Country: Netherlands

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MEDLINETA: J Dermatol Sci

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