Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection.

Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Research Abstract Details 

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Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Abstract Text:

Sumita Bhaduri-McIntosh,Marie L Landry,Sarah Nikiforow,Marisa Rotenberg,Ayman El-Guindy,George Miller,

Primary Epstein-Barr virus (EBV) infection is characterized by the presence of IgM antibodies to viral capsid antigen and the absence of antibodies to EB nuclear antigen. Here, using a flow cytometry-based assay, we investigated whether IgA antibodies are a marker for primary infection. Serum IgA antibodies in 15 individuals with primary EBV infection reacted with 15%-55.6% of HH514-16 Burkitt lymphoma cells expressing early lytic antigens (EAs), whereas IgA antibodies in serum samples from 15 healthy EBV-seropositive individuals reacted with 0.02%-2% of cells with EAs (P<.0001). IgA antibodies in primary infection were directed against the Bam Z Epstein-Barr replication activator (ZEBRA) (BZLF1) and diffuse EA (BMRF1) EAs. Thus, IgA antibodies to EBV EAs are produced during primary EBV infection and are likely to be stimulated as a result of lytic EBV replication in mucosal sites. Detection of IgA antibodies to EA may be developed into a diagnostic tool for primary EBV infection.

Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Publishing Authors By Initials

S Bhaduri-McIntosh,ML Landry,S Nikiforow,M Rotenberg,A El-Guindy,G Miller,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 483-92

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 10

MONTH: 01

YEAR: 2007

Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Information

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LANGUAGE: eng

NlmUniqueID: 413675

Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection.

AFFILIATION: Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NCI

GRANT: T32-CA09159

ACRONYM: CA

MEDLINETA: J Infect Dis

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