Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective.

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Abstract Text:

Robert J Goldberg,Daniel G Kramer,Darleen Lessard,Jorge Yarzebski,Joel M Gore,

BACKGROUND AND OBJECTIVES: Elevated serum glucose levels are associated with an increased risk of adverse outcomes in patients with diabetes in the setting of acute myocardial infarction. It is, however, unclear whether a similar association exists in nondiabetic patients and whether this relationship is changing over time. The objectives of this population-based investigation were to examine the magnitude of elevated glucose levels in patients with acute myocardial infarction and the association between admission serum glucose levels and hospital outcomes in patients not known to have prior diabetes. METHODS: The sample consisted of 3601 patients without a history of prior diabetes who were hospitalized with acute myocardial infarction at all greater Worcester (Massachusetts) medical centers in five biennial periods between 1995 and 2003. RESULTS: The average age of our study population was 70 years, 59% were men, and the average glucose level at the time of hospital admission was 149 mg/dl. Approximately one-third of patients presented with glucose levels<120 mg/dl, whereas one-quarter had serum glucose levels>or=160 mg/dl. Patients in the uppermost quintiles of serum glucose were significantly more likely to develop heart failure and cardiogenic shock, and die during hospitalization than patients with lower serum glucose levels. Patients with the highest glucose levels were less aggressively treated with effective cardiac medications and coronary interventions. CONCLUSIONS: The results of this population-based investigation provide insights into the magnitude and impact of hyperglycemia in patients not known to have prior diabetes who are hospitalized with acute myocardial infarction. Increased surveillance and more aggressive treatment strategies are needed to improve the outlook of patients with elevated serum glucose levels.

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Publishing Authors By Initials

RJ Goldberg,DG Kramer,D Lessard,J Yarzebski,JM Gore,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

PUBMED ID PMID:

MEDLINE DATE:

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Coronary artery disease

VOLUME: 18

Page Numbers: 125-31

Journal Abbreviation: Coron. Artery Dis.

ISSN: 0954-6928

DAY: 3

MONTH: Mar

YEAR: 2007

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9011445

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: etiology

Chemical & Substance for Abstract: Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective.

AFFILIATION: Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. goldberr@ummhc.org

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL35434

ACRONYM: HL

MEDLINETA: Coron Artery Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective Related Publications

• A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.
• A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.
• Adverse childhood experiences and mental health in young adults: a longitudinal survey.
• Amphibian emergency medicine.
• An Arabidopsis haplotype map takes root.
• Assessing functional connectivity in the human brain by fMRI.
• Assessing signal enhancement in distant dipolar field-based sequences.
• Calculation of RF Peak Power for 2D Arbitrary Shape Excitation in MRI.
• Comment on "Assessing functional connectivity in the human brain by fMRI".
• Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data.
• Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection.
• Development of 2dTCA for the detection of irregular, transient bold activity.
• Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention.
• Effects of hypoglycemia on human brain activation measured with fMRI.
• Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle.
• Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.
• Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
• Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results.
• Long-term trends in the use of coronary reperfusion strategies in acute myocardial infarction: a community-wide perspective.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography.
• Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals.
• Numerical study of water diffusion in biological tissues using an improved finite difference method.
• Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.
• Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times.
• Randomized adjuvant therapy trials in melanoma: surgical and systemic.
• Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T.
• Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective.
• The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats.
• Tracking the migration of dendritic cells by in vivo optical imaging.
• Why endocrinologists need to take ownership of endocrine disruption.