Serum biomarkers for Alzheimer's disease: proteomic discovery.

Serum biomarkers for Alzheimer's disease: proteomic discovery. Research Abstract Details 

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Serum biomarkers for Alzheimer's disease: proteomic discovery. Abstract Text:

Dwight C German,Prem Gurnani,Animesh Nandi,Harold R Garner,Wayne Fisher,Ramon Diaz-Arrastia,Padraig O'Suilleabhain,Kevin P Rosenblatt,

For Alzheimer's disease (AD), the most common neurodegenerative disease, there is no simple, cost-effective biomarker for disease identification. Using novel mass spectrometry (MS)-based techniques, and analysis of the albumin-enriched low molecular weight proteome, minute amounts of human serum were analyzed for the measurement of thousands of peptides and proteins in parallel. The mass spectrograms were then evaluated with a novel computer algorithm to identify spectral peaks that discriminate between samples from patients with and without AD. There are four peaks that distinguish AD from control subjects and AD subjects from those with Parkinson's disease (PD). Additionally, after analyzing data from a recently published study of AD and control subjects, we found three discriminating peaks in common with the four from our patient serum samples. The identification of these peptides/proteins, and their direct measurement in patient serum, may allow the development of a simple, cost-effective test for AD.

Serum biomarkers for Alzheimer's disease: proteomic discovery. Publishing Authors By Initials

DC German,P Gurnani,A Nandi,HR Garner,W Fisher,R Diaz-Arrastia,P O'Suilleabhain,KP Rosenblatt,

For similar proteins: albumins: serum albumin research abstracts see: proteins: albumins: serum albumin research

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Serum biomarkers for Alzheimer's disease: proteomic discovery. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biomedicine & pharmacotherapy = Biomédecine & phar

VOLUME: 61

Page Numbers: 383-9

Journal Abbreviation: Biomed. Pharmacother.

ISSN: 0753-3322

DAY: 18

MONTH: 06

YEAR: 2007

Serum biomarkers for Alzheimer's disease: proteomic discovery. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8213295

Serum biomarkers for Alzheimer's disease: proteomic discovery. Keywords Mesh Terms:

KEYWORDS: Serum Albumin

MESH TERMS: methods

Chemical & Substance for Abstract: Serum biomarkers for Alzheimer's disease: proteomic discovery. Information

Substance Name: Serum Albumin

Registry Number: 0

Grant and Affiliation Information for Serum biomarkers for Alzheimer's disease: proteomic discovery.

AFFILIATION: Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9070, USA. dwight.german@utsouthwestern.edu

Country: France

AGENCY: United States NIAID

GRANT: U54AI057156

ACRONYM: AI

MEDLINETA: Biomed Pharmacother

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