Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease.

Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Research Abstract Details 

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Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Abstract Text:

Richard Malley,Marc Lipsitch,Debby Bogaert,Claudette M Thompson,Peter Hermans,A Claire Watkins,Sanjay Sethi,Timothy F Murphy,

Antibodies to pneumococcus are thought to represent the primary mechanism of naturally acquired resistance to colonization. Here, however, we show that, in patients with chronic obstructive pulmonary disease (COPD), resistance to pneumococcal colonization is not associated with higher concentrations of serum anti-capsular or -noncapsular antibodies. We compared preacquisition serum antibody concentrations to capsular antigens 6B, 7F, 14, 19F, and 23F from patients with COPD who did and did not acquire pneumococcal respiratory tree colonization over the course of 2 years. Colonized patients did not have lower anti-capsular antibody concentrations than control subjects who did not acquire pneumococcus. We found no difference in functional antibody concentrations between colonized patients and control subjects. Furthermore, colonized patients had significantly higher preacquisition concentration of antibody directed against the whole cell and pneumococcal surface protein A than control subjects. We thus conclude that, in adult patients with COPD, resistance to pneumococcal colonization is unlikely to be determined by higher serum antibody concentrations to pneumococcal antigens.

Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Publishing Authors By Initials

R Malley,M Lipsitch,D Bogaert,CM Thompson,P Hermans,AC Watkins,S Sethi,TF Murphy,

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research

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Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 928-35

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 7

MONTH: 08

YEAR: 2007

Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Information

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LANGUAGE: eng

NlmUniqueID: 413675

Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Keywords Mesh Terms:

KEYWORDS: Streptococcus pneumoniae

MESH TERMS: immunology

Chemical & Substance for Abstract: Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. Information

Substance Name: pneumococcal surface protein A

Registry Number: 0

Grant and Affiliation Information for Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease.

AFFILIATION: Division of Infectious Diseases, Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Richard.Malley@childrens.harvard.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI048935

ACRONYM: AI

MEDLINETA: J Infect Dis

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