Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island.

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Research Abstract Details 

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Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Abstract Text:

Robert Philibert,Anup Madan,Allan Andersen,Remi Cadoret,Hans Packer,Harinder Sandhu,

The serotonin reuptake transporter (5HTT) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness. In attempt to understand the basis of this regulation, several gene polymorphisms that affect 5HTT mRNA levels have been described. But to date, no clear mechanism linking these polymorphisms to vulnerability to epigenetic effects have been described. In this communication, we describe a CpG island in the 5' region of the 5HTT gene that contains an alternative exon 1 and possible promoter for 5HTT. We then confirm the existence of this transcript and ascertain the methylation status of this CpG island in 49 lymphoblast cell lines and analyze the relationship between methylation and 5HTT mRNA levels. We demonstrate that methylation at this CpG island is associated with decreased levels of 5HTT mRNA, but that this effect is evident only when 5HTTLPR genotype is taken into account. We suggest that these findings have significant implications for the understanding of the role of this locus in behavioral illness.

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Publishing Authors By Initials

R Philibert,A Madan,A Andersen,R Cadoret,H Packer,H Sandhu,

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Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 144

Page Numbers: 101-5

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 5

MONTH: Jan

YEAR: 2007

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Information

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LANGUAGE: eng

NlmUniqueID: 101235742

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Keywords Mesh Terms:

KEYWORDS: Serotonin Plasma Membrane Transport Prot

MESH TERMS: genetics

Chemical & Substance for Abstract: Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Information

Substance Name: Serotonin Plasma Membrane Transport Prot

Registry Number: 0

Grant and Affiliation Information for Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island.

AFFILIATION: Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, Iowa, USA. robert-philibert@uiowa.edu

Country: United States

AGENCY: United States NIDA

GRANT: R01DA015789

ACRONYM: DA

MEDLINETA: Am J Med Genet B Neuropsychiat

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