An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg). Propofol infusion rapidly normalized his agitation, neuromuscular hyperactivity, and autonomic instability. Confirmatory analysis demonstrated a dextromethorphan serum concentration of 930 ng/mL. Dextromethorphan can produce serotonin syndrome in the absence of another serotonergic drug.
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Publishing Authors By Initials
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Journal Published:
PUBLICATION TYPE: Journal Article
Journal: Pediatric emergency care
VOLUME: 23
Page Numbers: 829-31
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ISSN: 1535-1815
DAY: 16
MONTH: Nov
YEAR: 2007
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Information
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LANGUAGE: eng
NlmUniqueID: 8507560
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Grant and Affiliation Information for Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.
AFFILIATION: Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. mganetsky@comcast.net
Country: United States
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MEDLINETA: Pediatr Emerg Care
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