Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder.

Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. Research Abstract Details 

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Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. Abstract Text:

Kristina Annerbrink,Marie Olsson,Lydia K Melchior,Jan Hedner,Elias Eriksson,

To elucidate if serotonergic transmission affects respiratory variability, a parameter consistently found increased in patients with panic disorder, we studied the effect of a serotonin synthesis inhibitor, para-chlorophenylalanine (PCPA), on respiratory variability at baseline and during CO2-induced hyperventilation in awake and unrestrained rats. Forty male Wistar rats were given intraperitoneal injections of PCPA (300 mg/kg) or saline 72, 48 and 24 h before registration of respiration in a plethysmograph allowing the animals to move freely. PCPA-treated rats displayed significantly higher tidal volume variability and minute volume variability, both at baseline and during CO2 exposure, compared to controls. The results support the notion that serotonin dysfunction may contribute to the enhanced respiratory variability observed in patients with panic disorder.

Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. Publishing Authors By Initials

K Annerbrink,M Olsson,LK Melchior,J Hedner,E Eriksson,

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Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The international journal of neuropsychopharmacolo

VOLUME: 6

Page Numbers: 51-6

Journal Abbreviation: Int. J. Neuropsychopharmacol.

ISSN: 1461-1457

DAY: 5

MONTH: Mar

YEAR: 2003

Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9815893

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AFFILIATION: Department of Pharmacology, Göteborg University, Box 431, SE 405 30 Göteborg, Sweden.

Country: England

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MEDLINETA: Int J Neuropsychopharmacol

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