Serotonin and neuroprotection in functional bowel disorders.

Serotonin and neuroprotection in functional bowel disorders. Research Abstract Details 

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Serotonin and neuroprotection in functional bowel disorders. Abstract Text:

M D Gershon,M-T Liu,

The 5-HT(4) partial agonist tegaserod is effective in the treatment of chronic constipation and constipation predominant irritable bowel syndrome. 5-HT(4) receptors are located on presynaptic terminals in the enteric nervous system. Stimulation of 5-HT(4) receptors enhances the release of acetylcholine and calcitonin gene related peptide from stimulated nerve terminals. This action strengthens neurotransmission in prokinetic pathways, enhancing gastrointestinal motility. The knockout of 5-HT(4) receptors in mice not only slows gastrointestinal activity but also, after 1 month of age, increases the age-related loss of enteric neurons and decreases the size of neurons that survive. 5-HT(4) receptor agonists, tegaserod and RS67506, increase numbers of enteric neurons developing from precursor cells and/or surviving in culture; they also increase neurite outgrowth and decrease apoptosis. The 5-HT(4) receptor antagonist, GR113808, blocks all of these effects, which are thus specific and 5-HT(4)-mediated. 5-HT(4) receptor agonists, therefore, are neuroprotective and neurotrophic for enteric neurons. Because the age-related decline in numbers of enteric neurons may contribute to the dysmotilities of the elderly, the possibility that the neuroprotective actions of 5-HT agonists can be utilized to prevent the occurrence or worsening of these conditions should be investigated.

Serotonin and neuroprotection in functional bowel disorders. Publishing Authors By Initials

MD Gershon,MT Liu,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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MEDLINE DATE:

Serotonin and neuroprotection in functional bowel disorders. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurogastroenterology and motility : the official

VOLUME: 19 Suppl 2

Page Numbers: 19-24

Journal Abbreviation: Neurogastroenterol. Motil.

ISSN: 1350-1925

DAY: 3

MONTH: Aug

YEAR: 2007

Serotonin and neuroprotection in functional bowel disorders. Information

Number of References: 44

LANGUAGE: eng

NlmUniqueID: 9432572

Serotonin and neuroprotection in functional bowel disorders. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Serotonin and neuroprotection in functional bowel disorders. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for Serotonin and neuroprotection in functional bowel disorders.

AFFILIATION: Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. mdg4@columbia.edu

Country: England

AGENCY: United States NINDS

GRANT: NS15547

ACRONYM: NS

MEDLINETA: Neurogastroenterol Motil

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