Serotonergic polymorphisms and psychotic disorders in populations from North Spain.

Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Research Abstract Details 

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Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Abstract Text:

There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N = 257) and in ethnically matched controls (N = 334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (P < or = 0.05) indicating a minor contribution to psychosis of genetic alterations in this gene.

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Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 126B

Page Numbers: 88-94

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 1

MONTH: Apr

YEAR: 2004

Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Information

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LANGUAGE: eng

NlmUniqueID: 101235742

Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Keywords Mesh Terms:

KEYWORDS: Spain

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Serotonergic polymorphisms and psychotic disorders in populations from North Spain. Information

Substance Name: Receptor, Serotonin, 5-HT2A

Registry Number: 0

Grant and Affiliation Information for Serotonergic polymorphisms and psychotic disorders in populations from North Spain.

AFFILIATION: Fundacion Argibide, Pamplona, Navarre, Spain.

Country: United States

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MEDLINETA: Am J Med Genet B Neuropsychiat

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