Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response.

Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. Research Abstract Details 

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Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. Abstract Text:

R Bendall,V Ellis,S Ijaz,P Thurairajah,H R Dalton,R Bendall,V Ellis,S Ijaz,P Thurairajah,H R Dalton,

Sequential sera were collected from 18 acute cases of UK-acquired hepatitis E. The virus strains in all cases were of genotype 3. The IgM and IgG response to acute infection were documented over time using EIA kits based on a peptide antigen, pE2, which is derived from a genotype 1 strain of hepatitis E virus (HEV). Ninety-five percentage of acute sera were IgM positive; after 6 months or more only 12% remained positive. The kit was adapted to quantify the IgG response (in WHO U/ml) and to determine antibody avidity. Following acute infection, anti-HEV IgG concentrations rose between 6.9- and 90-fold. IgG avidity was low (<25%) in most acute sera. After 6 months IgG avidity was greater than 50% in all cases. One patient with a poor IgM response and high avidity antibody in acute sera may have had a second HEV infection. Taken together, these results confirm that the pE2-based EIA kits are suitable for diagnosing acute HEV genotype 3 infection. With simple modifications the IgG kit can measure anti-HEV concentration and avidity, which can be used to confirm acute infection.

Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. Publishing Authors By Initials

R Bendall,V Ellis,S Ijaz,P Thurairajah,HR Dalton,R Bendall,V Ellis,S Ijaz,P Thurairajah,HR Dalton,

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Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical virology

VOLUME: 80

Page Numbers: 95-101

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 6

MONTH: Jan

YEAR: 2008

Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response.

AFFILIATION: Department of Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, Cornwall, UK. richard.bendall@rcht.cornwall.nhs.uk

Country: United States

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MEDLINETA: J Med Virol

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