Serologic and molecular investigations of a chimera.

Serologic and molecular investigations of a chimera. Research Abstract Details 

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Serologic and molecular investigations of a chimera. Abstract Text:

A chimeric individual possesses two or more genetically distinct cell populations. Although the chimerism may not be evident in all gene systems, various loci display greater numbers of alleles than genetically "normal" individuals. The proposita was referred for further laboratory investigation due to a mixed-field ABO blood group reaction following routine antenatal testing. Various molecular (HLA class II, ABO genotyping, and 10 short tandem repeat [STR] microsatellites) and serologic (HLA class I and red cell blood groups) typing techniques were employed to investigate a number of polymorphic loci located on different chromosomes. Chimerism was identified in 8 out of the 14 chromosomes tested: chromosome 1 (Duffy), 6 (HLA class I and II), 9 (ABO), 11 (HUMTH01), 12 (HUMPLA2A1), 15 (HUMFES/FPS), 18 (Kidd) and 21 (D21S11). The proposita was determined to be a probable dispermic chimera, based on the results of the serology and molecular studies.

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PUBLICATION TYPE: Journal Article

Journal: Immunohematology / American Red Cross

VOLUME: 15

Page Numbers: 100-4

Journal Abbreviation: Immunohematology

ISSN: 0894-203X

DAY: 8

MONTH: 04

YEAR: 1999

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LANGUAGE: eng

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AFFILIATION: Development Unit, Australian Red Cross Blood Service-Victoria.

Country: United States

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MEDLINETA: Immunohematology

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