Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy.

Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy. Research Abstract Details 

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Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy. Abstract Text:

Masamichi Takano,Masanori Yamamoto,Yong Xie,Daisuke Murakami,Shigenobu Inami,Kentaro Okamatsu,Koji Seimiya,Takayoshi Ohba,Yoshihiko Seino,Kyoichi Mizuno,Masamichi Takano,Masanori Yamamoto,Yong Xie,Daisuke Murakami,Shigenobu Inami,Kentaro Okamatsu,Koji Seimiya,Takayoshi Ohba,Yoshihiko Seino,Kyoichi Mizuno,

OBJECTIVE: Progression of neointimal stent coverage (NSC) and changes in thrombus were evaluated serially by coronary angioscopy for up to 2 years after sirolimus-eluting stent (SES) implantation. DESIGN: Serial angioscopic observations were performed in 20 segments of 20 patients at baseline, and at 6 months and 2 years after SES implantation. NSC was classified as follows: 0, uncovered struts; 1, visible struts through thin neointima; or 2, no visible struts. In each patient, maximum and minimum NSC was evaluated. Existence of thrombus was also examined. RESULTS: The maximum NSC increased from 6 months to 2 years (1.2 (0.4) vs 1.8 (0.4), respectively, p = 0.005), while the minimum NSC did not change (0.7 (0.5) vs 0.8 (0.4), respectively, p = 0.25). The prevalence of patients with uncovered struts did not decrease from 6 months to 2 years (35% vs 20%, respectively, p = 0.29). Although there were no thrombus-related adverse events, new thrombus formation was found in one patient (5%) at the 6-month, and in four patients (20%) at the 2-year follow-up evaluations. Frequencies of thrombus inside the SES at baseline, 6 months and 2 years did not differ one from another (40%, 40% and 30%, respectively; p = NS). CONCLUSIONS: Neointimal growth inside the SES progressed heterogeneously. Uncovered struts persisted in 20% of the patients for up to 2 years and subclinical thrombus formation was not a rare phenomenon.

Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy. Publishing Authors By Initials

M Takano,M Yamamoto,Y Xie,D Murakami,S Inami,K Okamatsu,K Seimiya,T Ohba,Y Seino,K Mizuno,M Takano,M Yamamoto,Y Xie,D Murakami,S Inami,K Okamatsu,K Seimiya,T Ohba,Y Seino,K Mizuno,

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Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Heart (British Cardiac Society)

VOLUME: 93

Page Numbers: 1533-6

Journal Abbreviation: Heart

ISSN: 1468-201X

DAY: 16

MONTH: Dec

YEAR: 2007

Serial long-term evaluation of neointimal stent coverage and thrombus after sirolimus-eluting stent implantation by use of coronary angioscopy. Information

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LANGUAGE: eng

NlmUniqueID: 9602087

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AFFILIATION: Department of Internal Medicine, Chiba-Hokusoh Hospital, Nippon Medical School, 1715 Kamakari, Imba, Chiba, 270-1694, Japan. takanom@nms.ac.jp

Country: England

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