Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change.

Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Research Abstract Details 

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Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Abstract Text:

Thirty-two outpatients with major depression of mild to moderate severity were given a 1 mg dexamethasone test (DST) after 1 week of placebo. Those who failed to show a response to placebo began a 6-week course of desipramine treatment. Severity ratings and the DST were repeated during biweekly visits. DST results robustly validated Winokur's familial subtyping and the primary/secondary distinction only when multiple results were considered. The use of multiple DSTs doubled the sensitivity of this test to primary depression and to familal pure depressive disorder without affecting specificity. Based on these data, a single abnormal DST result is considerably more meaningful than a single normal one. This finding may have particular importance to outpatients.

Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

PUBMED ID PMID:

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Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychiatry research

VOLUME: 10

Page Numbers: 165-74

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Nov

YEAR: 1983

Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: blood

Chemical & Substance for Abstract: Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. Information

Substance Name: Desipramine

Registry Number: 50-47-5

Grant and Affiliation Information for Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change.

AFFILIATION:

Country: NETHERLANDS

AGENCY: United States NCRR

GRANT: RR59

ACRONYM: RR

MEDLINETA: Psychiatry Res

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