Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.

Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Research Abstract Details 

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Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Abstract Text:

Heesik Yoon,Kevin L Legge,Sun-sang J Sung,Thomas J Braciale,

We have used a TCR-transgenic CD8+ T cell adoptive transfer model to examine the tempo of T cell activation and proliferation in the draining lymph nodes (DLN) in response to respiratory virus infection. The T cell response in the DLN differed for mice infected with different type A influenza strains with the onset of T cell activation/proliferation to the A/JAPAN virus infection preceding the A/PR8 response by 12-24 h. This difference in T cell activation/proliferation correlated with the tempo of accelerated respiratory DC (RDC) migration from the infected lungs to the DLN in response to influenza virus infection, with the migrant RDC responding to the A/JAPAN infection exhibiting a more rapid accumulation in the lymph nodes (i.e., peak migration for A/JAPAN at 18 h, A/PR8 at 24-36 h). Furthermore, in vivo administration of blocking anti-CD62L Ab at various time points before/after infection revealed that the virus-specific CD8+ T cells entered the DLN and activated in a sequential "conveyor belt"-like fashion. These results indicate that the tempo of CD8+ T cell activation/proliferation after viral infection is dependent on the tempo of RDC migration to the DLN and that T cell activation occurs in an ordered sequential fashion.

Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Publishing Authors By Initials

H Yoon,KL Legge,SS Sung,TJ Braciale,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 391-9

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: immunology

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Grant and Affiliation Information for Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.

AFFILIATION: Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 70065

ACRONYM: HL

MEDLINETA: J Immunol

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