Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer.

Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Research Abstract Details 

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Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Abstract Text:

Albert M Levin,Kimberly A Zuhlke,Anna M Ray,Kathleen A Cooney,Julie A Douglas,Albert M Levin,Kimberly A Zuhlke,Anna M Ray,Kathleen A Cooney,Julie A Douglas,

BACKGROUND: Expression of the alpha-methylacyl-CoA racemase (AMACR) gene has been established as a sensitive and specific biomarker for the diagnosis of prostate cancer. An initial study has also suggested that the risk of familial (but not sporadic) prostate cancer may be associated with germline variation in the AMACR gene. METHODS: In a study of brothers discordant for the diagnosis of prostate cancer (including 449 affected and 394 unaffected men) from 332 familial and early-onset prostate cancer families, we used conditional logistic regression and family-based association tests to investigate the association between prostate cancer and five single nucleotide polymorphisms (SNPs) tagging common haplotype variation within the coding and regulatory regions of AMACR. RESULTS: The strongest evidence for prostate cancer association was for SNP rs3195676, with an estimated odds ratio of 0.58 (95% confidence interval = 0.38-0.90; P = 0.01 for a recessive model). This non-synonymous SNP (nsSNP) results in a methionine-to-valine substitution at codon 9 (M9V) in exon 2 of the AMACR gene. Three additional nsSNPs showed suggestive evidence for prostate cancer association (P < or = 0.10). CONCLUSIONS: Our results confirm an initial report of association between the AMACR gene and the risk of familial prostate cancer. These findings emphasize the value of studying early-onset and familial prostate cancer when attempting to identify genetic variation associated with prostate cancer.

Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Publishing Authors By Initials

AM Levin,KA Zuhlke,AM Ray,KA Cooney,JA Douglas,AM Levin,KA Zuhlke,AM Ray,KA Cooney,JA Douglas,

For similar behavior and behavior mechanisms: psychology, social: family: nuclear family: siblings research abstracts see: behavior and behavior mechanisms: psychology, social: family: nuclear family: siblings research

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Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Prostate

VOLUME: 67

Page Numbers: 1507-13

Journal Abbreviation: Prostate

ISSN: 0270-4137

DAY: 1

MONTH: Oct

YEAR: 2007

Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8101368

Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Keywords Mesh Terms:

KEYWORDS: Siblings

MESH TERMS: genetics

Chemical & Substance for Abstract: Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. Information

Substance Name: alpha-methylacyl-CoA racemase

Registry Number: EC 5.1.99.4

Grant and Affiliation Information for Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer.

AFFILIATION: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA79596

ACRONYM: CA

MEDLINETA: Prostate

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