Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions.

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Abstract Text:

Minfeng Li,Kazuhiro Yamato,Joseph S Ferguson,Bing Gong,

Oligoamide strands that associate in a sequence-specific fashion into hydrogen-bonded duplexes in nonpolar solvents were converted into disulfide cross-linked duplexes in aqueous media. Thus, by incorporating trityl-protected thiol groups, which allows the reversible formation of disulfide bonds, into the oligoamide strands, only duplexes consisting of complementary hydrogen-bonding sequences were formed in aqueous solution as well as in methanol. The sequence-specific cross-linking of oligoamide strands was confirmed by MALDI-TOF, reverse-phase HPLC, and by isolating a cross-linked duplex. This study demonstrates that the sequence-specificity characteristic of multiply hydrogen-bonded systems can be extended into competitive media through the interplay of H-bonding and reversible covalent interactions, based on which a new class of molecular associating and ligating units that are compatible with both polar and nonpolar environments can be conveniently obtained.

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Publishing Authors By Initials

M Li,K Yamato,JS Ferguson,B Gong,

For similar water research abstracts see: water research

PUBMED ID PMID:

MEDLINE DATE:

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 12628-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 4

MONTH: Oct

YEAR: 2006

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions.

AFFILIATION: Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions Related Publications

• Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation.
• Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells.
• Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells.
• The identification and characterization of a testis-specific cDNA during spermatogenesis.
• Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells.
• Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults.
• [Advance of study on effects of Chfr gene of mitosis prophase checkpoint--review]
• [Application of rat tail collagen in the primary culture of rats marginal cells of stria vascularis]
• [Association of bone mineral density with gene polymorphisms and environmental factors in Chinese postmenopausal women]
• [Characteristics and operation of enhanced continuous bio-hydrogen production reactor using support carrier]
• [Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
• [Comparative study of binding power of polymyxin B and its simulating peptide to lipopolysaccharides lipoid A]
• [Correlation of receptor-mediated apoptosis to cell cycle]
• [Culture conditions and analysis of amanitins on Amanita spissa]
• [Detection of HIV DNA in Chinese AIDS kidney by in situ PCR]
• [Determination of trace mercury in the Chinese traditional medicine by hydride generation-atomic fluorescence spectrometry]
• [Effect of angiotensin II on L-type calcium channel in ischemic ventricular myocytes of the guinea pig]
• [Effect of the two types of TNF-alpha on the biological functions of monocytic cell line U937]
• [Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats]
• [Evaluation of stability of distal radius fracture after conservative treatment]
• [Excitotoxic effects of glutamate on the in vitro spiral ganglion cells]
• [Expression of telomerase activity and c-myc and stimulatory protein 1 in human ameloblastoma]
• [Fluorescence quenching method for the determination of trace zirconium with 5'-nitor-salicylfluorone and hexadecyltrimethylammonium bromide]
• [Improvement of refolding efficiency of HLA-A2-peptide complex in vitro by preformed disulfide bonds in heavy chain]
• [Preparation of strong cation exchange packings based on monodisperse hydrophilic non-porous resins and their application for fast separation of proteins]
• [Studies on photoluminescence characteristics of curcumin in acrylamide polymer]
• [Study on determination of composition of complex by multiwavelength R factor method]
• [Study on the origin of H/RS cell and their biological behavior in Hodgkin lymphoma by using multiple mark techniques]
• [Study on vibrational spectra and structure of 4-mercaptopyridine monomer and dimer using density functional theory]
• [The frequency of API2-MALT1 fusion gene variants in MALT lymphoma and its correlation with apoptosis of MALT lymphoma]