Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5.

Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5. Research Abstract Details 

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Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5. Abstract Text:

Kyoung Yong Jeong,Haeseok Lee,Kwang Hyun Shin,Myung-hee Yi,Kyoung-jin Jeong,Chein-Soo Hong,Tai-Soon Yong,Kyoung Yong Jeong,Haeseok Lee,Kwang Hyun Shin,Myung-hee Yi,Kyoung-jin Jeong,Chein-Soo Hong,Tai-Soon Yong,Kyoung Yong Jeong,Haeseok Lee,Kwang Hyun Shin,Myung-hee Yi,Kyoung-jin Jeong,Chein-Soo Hong,Tai-Soon Yong,

BACKGROUND: The allergenicity of allergens could be influenced by amino acid substitutions in B- or T-cell epitope regions. The German cockroach is known to produce potent allergens inducing strong IgE-mediated allergic reactions. This study was performed to investigate sequence variations in major allergens of the German cockroach. METHODS: Reverse transcriptase PCR was used to amplify the cDNA sequences encoding major allergens of the German cockroach (Bla g 1, Bla g 2, Bla g 4, and Bla g 5). RESULTS: The deduced amino acid sequences revealed 38 Bla g 1 variants with 1-7 amino acid substitutions (98.6-99.8% identity), 28 Bla g 2 variants with 1-3 substitutions (99.1-99.7%), 27 Bla g 4 variants with 0-32 substitutions (82.4-100%), and 8 Bla g 5 variants with 1-2 substitutions (99.0-99.5%), respectively. Bla g 1 and Bla g 2 showed sporadic amino acid substitutions despite the divergence in their sequences. Bla g 4 exhibited frequent variations, with clusters of substitutions in residues 29-38, 52-80, and 132-155. Sequence variations in Bla g 4 imply the presence of multiple isoforms and isoallergens, which may in turn have various effects on the IgE-binding capacity and T-cell responsiveness. Only 8 variants were found in Bla g 5, with infrequent amino acid changes of one or two residues. CONCLUSIONS: Analyses of T-cell and IgE-binding epitope regions would clarify the effect of sequence polymorphisms on allergenicity, which in turn will aid in the design of allergen formulations for diagnosis and immunotherapy for cockroach allergies.

Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5. Publishing Authors By Initials

KY Jeong,H Lee,KH Shin,MH Yi,KJ Jeong,CS Hong,TS Yong,KY Jeong,H Lee,KH Shin,MH Yi,KJ Jeong,CS Hong,TS Yong,KY Jeong,H Lee,KH Shin,MH Yi,KJ Jeong,CS Hong,TS Yong,

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Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International archives of allergy and immunology

VOLUME: 145

Page Numbers: 1-8

Journal Abbreviation: Int. Arch. Allergy Immunol.

ISSN: 1423-0097

DAY: 16

MONTH: 08

YEAR: 2007

Sequence polymorphisms of major German cockroach allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5. Information

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LANGUAGE: eng

NlmUniqueID: 9211652

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AFFILIATION: Department of Parasitology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea.

Country: Switzerland

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MEDLINETA: Int Arch Allergy Immunol

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