Sept12 is a component of the mammalian sperm tail annulus.

Sept12 is a component of the mammalian sperm tail annulus. Research Abstract Details 

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Sept12 is a component of the mammalian sperm tail annulus. Abstract Text:

Jonathan D Steels,Mathew P Estey,Carol D Froese, Reynaud,Cecil Pace-Asciak,William S Trimble,Jonathan D Steels,Mathew P Estey,Carol D Froese, Reynaud,Cecil Pace-Asciak,William S Trimble,

Since their essential role in cytokinesis was first shown in yeast, the septins have been described to function in diverse cellular contexts. The members of this unique class of GTPases are capable of binding and hydrolyzing GTP, associating with membranes and oligomerizing into higher order structures. Here we describe Sept12, a novel septin, identified in a yeast two hybrid screen using Sept5 as the bait. Sept12 contains the primary sequence elements of a septin and is capable of interacting with other septins. In addition, Sept12 purifies with bound nucleotide and binds to phosphoinositides, confirming its identity as a septin. RT-PCR and Northern blots reveal that Sept12 mRNA is expressed predominantly in testis, and this is supported by tissue Western blots. In rats, Sept12 protein levels rise upon sexual maturity and the Sept12 protein colocalizes with the annulus in isolated mature spermatozoa. Further, coexpression of Sept12 with Sept4, an essential annulus component, results in complete colocalization of both proteins into robust and highly curved filaments in CHO cells. This study suggests Sept12 may be involved in mammalian fertility.

Sept12 is a component of the mammalian sperm tail annulus. Publishing Authors By Initials

JD Steels,MP Estey,CD Froese,D Reynaud,C Pace-Asciak,WS Trimble,JD Steels,MP Estey,CD Froese,D Reynaud,C Pace-Asciak,WS Trimble,

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Sept12 is a component of the mammalian sperm tail annulus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell motility and the cytoskeleton

VOLUME: 64

Page Numbers: 794-807

Journal Abbreviation: Cell Motil. Cytoskeleton

ISSN: 0886-1544

DAY: 17

MONTH: Oct

YEAR: 2007

Sept12 is a component of the mammalian sperm tail annulus. Information

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LANGUAGE: eng

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AFFILIATION: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Country: United States

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MEDLINETA: Cell Motil Cytoskeleton

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