Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Abstract Text:

Haiwang Tang,Lacramioara Ivanciu,Narcis Popescu,Glenn Peer,Erik Hack,Cristina Lupu,Fletcher B Taylor,Florea Lupu,Haiwang Tang,Lacramioara Ivanciu,Narcis Popescu,Glenn Peer,Erik Hack,Cristina Lupu,Fletcher B Taylor,Florea Lupu,

Increased tissue factor (TF)-dependent procoagulant activity in sepsis may be partly due to decreased expression or function of tissue factor pathway inhibitor (TFPI). To test this hypothesis, baboons were infused with live Escherichia coli and sacrificed after 2, 8, or 24 hours. Confocal and electron microscopy revealed increased leukocyte infiltration and fibrin deposition in the intravascular and interstitial compartments. Large amounts of TF were detected by immunostaining in leukocytes and platelet-rich microthrombi. TF induction was documented by quantitative reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and coagulation assays. Lung-associated TFPI antigen and mRNA decreased during sepsis, and TFPI activity diminished abruptly at 2 hours. Blocking antibodies against TFPI increased fibrin deposition in septic baboon lungs, suggesting that TF-dependent coagulation might be aggravated by reduced endothelial TFPI. Decreased TFPI activity coincided with the release of tissue plasminogen activator and the peak of plasmin generation, suggesting that TFPI could undergo proteolytic inactivation by plasmin. Enhanced plasmin produced in septic baboons by infusion of blocking antibodies against plasminogen activator inhibitor-1 led to decreased lung-associated TFPI and unforeseen massive fibrin deposition. We conclude that activation of TF-driven coagulation not adequately countered by TFPI may underlie the widespread thrombotic complications of sepsis.

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Publishing Authors By Initials

H Tang,L Ivanciu,N Popescu,G Peer,E Hack,C Lupu,FB Taylor,F Lupu,H Tang,L Ivanciu,N Popescu,G Peer,E Hack,C Lupu,FB Taylor,F Lupu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The American journal of pathology

VOLUME: 171

Page Numbers: 1066-77

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 19

MONTH: 07

YEAR: 2007

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.

AFFILIATION: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, OK 73104, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 5R01GM037704-17

ACRONYM: GM

MEDLINETA: Am J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor Related Publications

• "Crossroads in Sepsis Research" Review Series Overview of the pathophysiology of sepsis.
• A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2
• Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis.
• Electro-clinical considerations on some cases of van Bogaert's subacute leukoencephalitis.
• HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail".
• In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging.
• In vivo detection of c-Met expression in a rat C6 glioma model.
• Influence of impurities on the x-ray photoelectron spectroscopy and Raman spectra of single-wall carbon nanotubes.
• Laudatio to professor fletcher B. Taylor.
• Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).
• Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.
• Pneumohydrostatic device for goniotomy.
• Proportion of injured alcohol-impaired drivers subsequently convicted of an impaired driving criminal code offence in British Columbia.
• Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.
• Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis.
• Ultrasound guided spinal anesthesia.
• Up-regulation of alpha(v)beta(3) integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner.
• [Monitoring system for cardiovascular parameters of drivers]
• [Sjögren's syndrome. Etiopathogenetic comments on 3 clinical cases]