SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Research Abstract Details 

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SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Abstract Text:

Kee-Hong Kim,Yuan Gao,Ken Walder,Greg R Collier,Joseph Skelton,Ahmed H Kissebah,

Selenoprotein S (SEPS1) is a novel endoplasmic reticulum (ER) resident protein and it is known to play an important role in production of inflammatory cytokines. Here, we show evidence that SEPS1 is stimulated by pharmacological ER stress agents in RAW264.7 macrophages as well as other cell types. Overexpression studies reveal a protective action of SEPS1 in macrophages against ER stress-induced cytotoxicity and apoptosis, resulting in promoting cell survival during ER stress. The protective action of SEPS1 is largely dependent on ER stress-mediated cell death signal with less effect on non-ER stress component cell death signals. Conversely, suppression of SEPS1 in macrophages results in sensitization of cells to ER stress-induced cell death. These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction.

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Publishing Authors By Initials

KH Kim,Y Gao,K Walder,GR Collier,J Skelton,AH Kissebah,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidine nucleosides: tunicamycin research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidine nucleosides: tunicamycin research

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SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 354

Page Numbers: 127-32

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 2

MONTH: 01

YEAR: 2007

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 372516

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Keywords Mesh Terms:

KEYWORDS: Tunicamycin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Information

Substance Name: Thapsigargin

Registry Number: 67526-95-8

Grant and Affiliation Information for SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.

AFFILIATION: Division of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA. kkim@mcw.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK065598-03

ACRONYM: DK

MEDLINETA: Biochem Biophys Res Commun

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