Sensitizing tumor cells to immune-mediated cytotoxicity.

Sensitizing tumor cells to immune-mediated cytotoxicity. Research Abstract Details 

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Sensitizing tumor cells to immune-mediated cytotoxicity. Abstract Text:

Anil Shanker,Thomas Sayers,

The molecular basis underlying tumor destruction in vivo by specific antitumor CD8+ T cells remains unclear. We propose that the local production of certain tumor necrosis factor (TNF)-family members (death ligands) may be more important for tumor destruction in vivo than previously thought. Also, the apoptotic response of some tumor cells to the TNF-family member TRAIL can be augmented by the proteasome inhibitor bortezomib (Velcade). Thus, bortezomib may sensitize tumor cells to T cell-mediated cytotoxicity and could potentially improve the beneficial effects of immunotherapy.

Sensitizing tumor cells to immune-mediated cytotoxicity. Publishing Authors By Initials

A Shanker,T Sayers,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

PUBMED ID PMID:

MEDLINE DATE:

Sensitizing tumor cells to immune-mediated cytotoxicity. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in experimental medicine and biology

VOLUME: 601

Page Numbers: 163-71

Journal Abbreviation: Adv. Exp. Med. Biol.

ISSN: 0065-2598

DAY: 3

MONTH: 12

YEAR: 2007

Sensitizing tumor cells to immune-mediated cytotoxicity. Information

Number of References: 18

LANGUAGE: eng

NlmUniqueID: 121103

Sensitizing tumor cells to immune-mediated cytotoxicity. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sensitizing tumor cells to immune-mediated cytotoxicity. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Sensitizing tumor cells to immune-mediated cytotoxicity.

AFFILIATION: Cancer and Inflammation Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.

Country: United States

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: Adv Exp Med Biol

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