Sensitization does not develop in utero.

Sensitization does not develop in utero. Research Abstract Details 

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Sensitization does not develop in utero. Abstract Text:

BACKGROUND: Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy. OBJECTIVE: To investigate the relevance of allergen-specific IgE in cord blood to sensitization in early infancy and the origin of such IgE. METHODS: Inhalant and food allergen-specific IgE in cord blood was analyzed and compared with specific IgE in infant blood at 6 months of age and in parental blood. Cord blood IgA was measured to detect maternal blood contamination of cord blood. RESULTS: Allergen-specific IgE, primarily against inhalant allergens, was detected in 14% of cord blood samples. However, corresponding specific IgE was not found in infant blood at 6 months of age. Specific IgE in cord blood completely matched specific IgE in maternal blood with respect to allergen specificity, level of specific IgE, and ratio of total IgE/specific IgE. Finally, there was a correlation between specific IgE and IgA in cord blood. CONCLUSION: Allergen-specific IgE in cord blood does not reflect intrauterine sensitization but seems to be the result of transfer of maternal IgE to the fetus.

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Sensitization does not develop in utero. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of allergy and clinical immunology

VOLUME: 121

Page Numbers: 646-51

Journal Abbreviation: J. Allergy Clin. Immunol.

ISSN: 1097-6825

DAY: 10

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 1275002

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AFFILIATION: Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark. kb@copsac.dk

Country: United States

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MEDLINETA: J Allergy Clin Immunol

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