Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix.

Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Research Abstract Details 

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Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Abstract Text:

Paul J Hauser,Zhiyong Han,Puneet Sindhwani,Robert E Hurst,

Because the response of cancer cells to chemotherapeutic agents depends upon the supporting extracellular matrix (ECM), the response in vivo may not be reproduced in 2-dimensional cell culture. The dose-response to curcumin and two derivatives by bladder cancer cells grown on both normal (SISgel) and cancer-derived ECM (Matrigel) and on plastic were contrasted. Cells grown on Matrigel were resistant to curcumins, but cells growing on SISgel, which mimic cancer cells suppressed by normal ECM, were nearly as sensitive as cells grown on plastic. SV40-immortalized urothelial cells, which are models for premalignant cells, were the most sensitive, but even aggressive cell lines were nearly as sensitive when grown on SISgel as on plastic. Curcumin response depends highly on the supporting ECM, and cells grown on plastic poorly models cells growing on natural ECM. Curcumin could prove an effective chemopreventive for bladder cancer recurrence when administered intravesically post-therapy.

Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Publishing Authors By Initials

PJ Hauser,Z Han,P Sindhwani,RE Hurst,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

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MEDLINE DATE:

Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anticancer research

VOLUME: 27

Page Numbers: 737-40

Journal Abbreviation:

ISSN: 0250-7005

DAY: 3

MONTH: 12

YEAR: 2007

Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102988

Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix.

AFFILIATION: Department of Urology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.

Country: Greece

AGENCY: United States NIDDK

GRANT: DK 069808

ACRONYM: DK

MEDLINETA: Anticancer Res

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