Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver.

Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Research Abstract Details 

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Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Abstract Text:

Michael S Hughes,Jon N Marsh,Kirk D Wallace,Tamara A Donahue,Anne M Connolly,Gregory M Lanza,Samuel A Wickline,

The dystrophinopathies comprise a group of X-linked genetic diseases that feature dystrophin deficiency. Duchenne and Becker muscular dystrophy are characterized by progressive weakness and wasting of skeletal, smooth, and/or cardiac muscle. Duchenne muscular dystrophy (DMD) is the most severe dystrophinopathy, with an incidence of 1:3500 male births. Despite understanding the structural and genetic basis for DMD, the pathogenesis and clinical basis for more severe involvement in specific skeletal muscle groups and the heart are poorly understood. Current techniques, such as strength testing for monitoring progress of disease and therapy in DMD patients, are imprecise and physically demanding for test subjects. Ultrasound is well-suited to detect changes in structure and organization in muscle tissue in a manner that makes low demands on the patient. Therefore, we investigated the use of ultrasound to quantitatively phenotype the remodeling process in patients with DMD. Beam-formed radio-frequency (RF) data were acquired from the skeletal muscles of nine DMD and five normal subjects imaged with a clinical imaging system (HDI5000 w/7 MHz probe applied above left biceps muscle). From these data, images were reconstructed using B-mode (log of analytic signal magnitude) and information-theoretic receivers (H(f)-receiver). H(f) images obtained from dystrophic muscle contained extensive "mottled" regions (i.e., areas with heterogeneous image contrast) that were not readily apparent from the B-Mode images. The 2-D autocorrelation of DMD H(f) images have broader peaks than those of normal subjects, which is indicative of larger scatterer sizes, consistent with pathologic changes of fibers, edema and fatty infiltration. Comparison of the relative peak widths (full width measured at 60% maximum) of the autocorrelation of the DMD and normal H(f) images shows a quantitative difference between the two groups (p < 0.005, student two-tailed paired t-test). Consequently, these imaging techniques may prove useful for longitudinal monitoring of disease progression and therapy.

Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Publishing Authors By Initials

MS Hughes,JN Marsh,KD Wallace,TA Donahue,AM Connolly,GM Lanza,SA Wickline,

For similar musculoskeletal diseases: muscular diseases: muscular disorders, atrophic: muscular dystrophies: muscular dystrophy, duchenne research abstracts see: musculoskeletal diseases: muscular diseases: muscular disorders, atrophic: muscular dystrophies: muscular dystrophy, duchenne research

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Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Ultrasound in medicine & biology

VOLUME: 33

Page Numbers: 1236-43

Journal Abbreviation:

ISSN: 0301-5629

DAY: 30

MONTH: 04

YEAR: 2007

Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 410553

Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Keywords Mesh Terms:

KEYWORDS: Muscular Dystrophy, Duchenne

MESH TERMS: ultrasonography

Chemical & Substance for Abstract: Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver. Information

Substance Name: Glucocorticoids

Registry Number: 0

Grant and Affiliation Information for Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver.

AFFILIATION: Washington University, School of Medicine, St Louis, MO 63108, USA. msh@cvu.wust.edu

Country: England

AGENCY: United States NCI

GRANT: U54 CA119342-01

ACRONYM: CA

MEDLINETA: Ultrasound Med Biol

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