Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Abstract Text:

Guodong Zhang,Alvin V Terry,Michael G Bartlett,Guodong Zhang,Alvin V Terry,Michael G Bartlett,Guodong Zhang,Alvin V Terry,Michael G Bartlett,

One prerequisite for therapeutic effects of psychiatric drugs is the ability to pass the blood brain barrier. Hence, it is important to know the concentration of antipsychotic drugs in brain tissue. In general, determinations of lipophilic compounds from lipophilic matricies such as the brain are a challenge. Here we have adapted a plasma assay for antipsychotics for the target organ the brain. Using modified sample preparation and chromatographic strategies, the analytes were extracted from rat brain homogenate and analyzed by LC-MS/MS. The method used a Waters Atlantis dC-18 (30 mm x 2.1 mm i.d., 3 microm) column with a mobile phase of acetonitrile/5 mM ammonium formate (pH 6.1 adjusted with formic acid) and gradient elution. All analytes were detected in positive ion mode using multiple-reaction monitoring. The method was validated and the linearity, lower limit of quantitation, precision, accuracy, recoveries, specificity and stability were determined. This method was then successfully used to quantify the rat brain tissue concentration of the analytes after chronic treatment with these antipsychotic drugs.

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Publishing Authors By Initials

G Zhang,AV Terry,MG Bartlett,G Zhang,AV Terry,MG Bartlett,G Zhang,AV Terry,MG Bartlett,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of chromatography. B, Analytical technolog

VOLUME: 858

Page Numbers: 276-81

Journal Abbreviation: J. Chromatogr. B Analyt. Techn

ISSN: 1570-0232

DAY: 17

MONTH: 08

YEAR: 2007

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101139554

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.

AFFILIATION: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: MH066233

ACRONYM: MH

MEDLINETA: J Chromatogr B Analyt Technol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue Related Publications

• A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus.
• A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115.
• Ab initio density functional theory applied to quasidegenerate problems.
• Are overweight and obese adults with arthritis being advised to lose weight?
• Beta strand peptidomimetics as potent PDZ domain ligands.
• Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic efficacy in human ovarian carcinoma.
• Complete cavopulmonary shunt completion after in utero balloon atrial septoplasty for hypoplastic left heart syndrome.
• Effect of resin coating on dentine compared to repeated topical applications of fluoride mouthwash after an abrasion and erosion wear regime.
• Extracorporeal support for septic shock.
• Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets.
• GABAergic processes mediate thermal prolongation of the laryngeal reflex apnea in decerebrate piglets.
• HNNC radical and its role in the CH+N2 reaction.
• Implants for life? A critical review of implant-supported restorations.
• Jealousy and the threatened self: getting to the heart of the green-eyed monster.
• Liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat plasma.
• Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor.
• Parkinson's disease.
• Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.
• Sensitive liquid chromatography/tandem mass spectrometry method for the determination of the lipophilic antipsychotic drug chlorpromazine in rat plasma and brain tissue.
• Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.
• Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection.
• Single agent bortezomib in the treatment of relapsed and refractory Hodgkin lymphoma: cancer and leukemia Group B protocol 50206.
• Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA.
• Strobilurin fungicides induce changes in photosynthetic gas exchange that do not improve water use efficiency of plants grown under conditions of water stress.
• Synthesis of amino acid-derived cyclic acyl amidines for use in beta-strand peptidomimetics.
• The microhardness of bleached dentine and its bond strength to a dentine bonding agent.
• Theriogenology: From concept to actuality.
• Transient global amnesia in a patient with acute unilateral caudate nucleus ischemia.
• Vibrio cholerae strains possess multiple strategies for abiotic and biotic surface colonization.
• What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood?