Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure.

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Abstract Text:

Y Hu,Z Zhou,X Xue,X Li,J Fu,B Cohen,A A Melikian,M Desai,M -S Tang,X Huang,N Roy,J Sun,P Nan,Q Qu,

The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 microg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 microg m-3; and those in gardeners were 0.011, 0.020 and 0.008 microg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at < 0.010 and > 0.010 but < 0.020 microg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Publishing Authors By Initials

Y Hu,Z Zhou,X Xue,X Li,J Fu,B Cohen,AA Melikian,M Desai,MS Tang,X Huang,N Roy,J Sun,P Nan,Q Qu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biomarkers : biochemical indicators of exposure, r

VOLUME: 11

Page Numbers: 306-18

Journal Abbreviation:

ISSN: 1354-750X

DAY: 3

MONTH: 12

YEAR: 2007

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9606000

Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure.

AFFILIATION: Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biomarkers

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sensitive biomarker of polycyclic aromatic hydrocarbons PAHs: urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure Related Publications

• Acoustic grating fringe projector for high-speed and high-precision three-dimensional shape measurements.
• Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy development.
• Designing a Signal Conditioning System with Software Calibration for Resistor-feedback Patch Clamp Amplifier.
• Optimal expression condition of recombinant RAP.
• Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.
• Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure.
• Systems biology approaches to metabolic and cardiovascular disorders: network perspectives of cardiovascular metabolism.
• Three-Dimensional Tracking of Single Granules in Living PC-12 Cells Employing TIRFM and WFFM.
• [Achievements in the mosquito study in China in 50 years]
• [Analysis of RPE damage after photodynamic therapy in patients with idiopathic choroidal neovascularization]
• [Analysis of the long-term outcome of anterior approach surgery on cervical spondylotic myelopathy]
• [Apoptosis of cultured cortical neurons of rat's brain induced by heroin]
• [Arthroscopically assisted anterior cruciate ligament reconstruction using patellar tendon autograft fixed with interference screw]
• [CT features and anatomic-pathologic basis of the 16-slice spiral CT for aortic dissection]
• [Coagulation behavior of Al13 species]
• [Construction of GPI-CTLA4Ig chimeric molecule and its expression on CHO-dhfr(-) cells]
• [Effect of some active Chinese herbal fraction on brain tissue proteomic profile of ischemic mouse]
• [Effects of cardiac sympathetic blockade on left ventricular diastolic function in patients with dilated cardiomyopathy and severe heart failure]
• [Electrochemical hydrodehalogenation of pentachloraphenol in aqueous solution by porous titanium loaded Pd cathode]
• [Expression of muscarinic acetylcholine receptor-11 in human retinal pigment epithelium]
• [Genetic diversity of Coptis chinensis germplasm based on ISSR analysis]
• [Impact of STAT6 signaling pathway blockade on apoptosis of human colon cancer cells]
• [Influence of chronic ethanol intake insulin sensitivity and IR, IRS-1, IRS-2 mRNA expression of liver in male rats]
• [Inhibitory effects of matrix metalloproteinase (MMP) inhibitor LY52 on expression of MMP-2 and MMP-9 and invasive ability of human ovarian carcinoma cell line SKOV3]
• [Isolation and purification of eccrine sweat glands in human skin.]
• [Medical thoracoscopy in the diagnosis of complicate pleural effusion]
• [Re-osseointegration of peri-implantitis bone defects: an experimental study in dogs]
• [Retrospective analysis on 116 cases of bradyarrhythmia treated with TCM based syndrome differentiation]
• [Studies on chemical constituents from roots of Craibiodendron henryi]
• [Study on influence between activated carbon property and immobilized biological activated carbon purification effect]