Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time.

Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Research Abstract Details 

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Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Abstract Text:

Chris P Geffre,Cody L Bliss,John A Szivek,Donald W Deyoung,John T Ruth,David S Margolis,Chris P Geffre,Cody L Bliss,John A Szivek,Donald W Deyoung,John T Ruth,David S Margolis,Chris P Geffre,Cody L Bliss,John A Szivek,Donald W Deyoung,John T Ruth,David S Margolis,

Polymer scaffolds have been used as a tool to provide growth and integration of engineered tissue substrates to repair damaged tissues in many organ systems including articular cartilage. Previous work has shown that "sensate" scaffolds, with integrated strain gauges have the potential for use as both a delivery vehicle for engineered cartilage as well as a device that can measure real time, in vivo joint loading. The purpose of this study was to use an implanted subminiature telemetry system to collect in vivo joint loading measurements over an extended period following placement of a "sensate" scaffold. Measurements were collected from seven of nine sensors that were implanted into the stifles of three canines. The limb loading rates and load distribution through gait were dependent on stride time but did not vary with time post op. The peak loads were not dependent on stride time but significantly increased with time post op. This demonstrated that peak loading measured with "sensate" scaffolds can be used to monitor healing. The portability of the "sensate" scaffolds coupled to telemetry systems highlights the potential use of this system in a clinical research setting to gather important information to improve tissue engineering and rehabilitation regimens. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008.

Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Publishing Authors By Initials

CP Geffre,CL Bliss,JA Szivek,DW Deyoung,JT Ruth,DS Margolis,CP Geffre,CL Bliss,JA Szivek,DW Deyoung,JT Ruth,DS Margolis,CP Geffre,CL Bliss,JA Szivek,DW Deyoung,JT Ruth,DS Margolis,

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Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part B,

VOLUME: 84

Page Numbers: 263-70

Journal Abbreviation: J. Biomed. Mater. Res. Part B

ISSN: 1552-4973

DAY: 11

MONTH: Jan

YEAR: 2008

Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. Information

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LANGUAGE: eng

NlmUniqueID: 101234238

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Grant and Affiliation Information for Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time.

AFFILIATION: Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Arizona, Tucson, Arizona.

Country: United States

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MEDLINETA: J Biomed Mater Res B Appl Biom

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