Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease.

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Abstract Text:

M Yamada,Y Itoh,N Sodeyama,N Suematsu,E Otomo,M Matsushita,H Mizusawa,

A subset of senile dementia, 'senile dementia (SD) of the neurofibrillary tangle (NFT) type' (SD-NFT), is characterized by numerous NFTs in the hippocampal region and absence or scarcity of senile plaques throughout the brain. To elucidate the pathogenesis of SD-NFT in comparison with Alzheimer's disease (AD), we investigated the hippocampal lesions and analyzed the tau gene. The hippocampal regions from 5 patients with SD-NFT were neuropathologically evaluated in comparison with AD and nondemented control subjects. The tau gene was analyzed in 3 patients with SD-NFT. The densities of NFTs in the CA1/subiculum and entorhinal cortex of SD-NFT were significantly higher than those in AD. However, hippocampal atrophy, neuronal and synaptic loss, and astrocytic and microglial proliferation in SD-NFT were significantly mild compared with AD. There was no significant difference between SD-NFT and AD in the immunoreactivities of NFTs with different anti-tau antibodies. No mutation was found in the tau gene from the SD-NFT patients. Our results indicate that the neurodegenerative process with NFT formation of the hippocampal region in SD-NFT would be different from that in AD.

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Publishing Authors By Initials

M Yamada,Y Itoh,N Sodeyama,N Suematsu,E Otomo,M Matsushita,H Mizusawa,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

PUBMED ID PMID:

MEDLINE DATE: 2001 Mar-Apr

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Dementia and geriatric cognitive disorders

VOLUME: 12

Page Numbers: 117-26

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9705200

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Information

Substance Name: tau Proteins

Registry Number: 0

Grant and Affiliation Information for Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease.

AFFILIATION: Department of Neurology, Kanazawa University School of Medicine, Kanazawa, Japan. m-yamada@med.kanazawa-u.ac.jp

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dement Geriatr Cogn Disord

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease Related Publications

• Antihistamine-associated myoclonus: A case report.
• Association of neprilysin polymorphism with cerebral amyloid angiopathy.
• Chiasmal optic neuritis following mumps parotitis.
• Chromosomal instability in human mesenchymal stem cells immortalized with human papilloma virus E6, E7, and hTERT genes.
• Coexistence of CJD and Alzheimer's disease: an autopsy case showing typical clinical features of CJD.
• Direct and accurate measurement of CAG repeat configuration in the ataxin-1 (ATXN-1) gene by "dual-fluorescence labeled PCR-restriction fragment length analysis".
• Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke.
• Lack of genetic associations of alpha-1-antichymotrypsin polymorphism with alzheimer-type neuropathological changes or sporadic Alzheimer's disease.
• Proximal motor conduction evaluated by transcranial magnetic stimulation in acquired inflammatory demyelinating neuropathies.
• Pseudoradicular sensory loss caused by a cerebral demyelinative lesion.
• Pure pandysautonomia associated with interferon-alpha therapy.
• Recurrent aseptic meningitis: a new CSF complication of Sjogren's syndrome.
• Reversibility of cerebellar GABAergic synapse impairment induced by anti-glutamic acid decarboxylase autoantibodies.
• Reversible central neurogenic hyperventilation in an awake patient with multiple sclerosis.
• Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease.
• Three-layered structure shared between lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections.
• Vagus nerve palsy caused by varicella zoster virus infection without rash.
• [An 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency]
• [Detection of the primary tumor site in tumor-induced osteomalacia by indium-111 octreotide scintigraphy: a case report]
• [Intrathecal baclofen therapy to spasticity]
• [Tailored therapy for multiple sclerosis]