Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice.

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Research Abstract Details 

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Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Abstract Text:

Jennifer Kelly,Aslam Ali Khan,Jiyi Yin,Thomas A Ferguson,Rajendra S Apte,Jennifer Kelly,Aslam Ali Khan,Jiyi Yin,Thomas A Ferguson,Rajendra S Apte,

Abnormal angiogenesis plays a key role in diseases of aging such as heart disease, certain cancers, and eye diseases including age-related macular degeneration. Macrophages have been shown previously to be both anti- and proangiogenic, and their role in regulating angiogenesis at sites of tissue injury is critical and complex. In this study, we analyzed cytokine gene expression patterns of mouse macrophages by real-time quantitative PCR and tested the functional effects of senescence on gene expression and macrophage polarization. Following laser injury to the retina, IL-10 was upregulated and Fas ligand (FasL), IL-12, and TNF-alpha were downregulated in ocular macrophages of old mice (>18 months of age). Downregulation of FasL on macrophages led to a loss of the antiangiogenic phenotype, as evidenced by the inability of these macrophages to inhibit vascular endothelial cells. Our results demonstrate that senescence, FasL, and IL-10 are key determinants of macrophage function that alter the growth of abnormal postdevelopmental blood vessels in disease processes including blinding eye disease.

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Publishing Authors By Initials

J Kelly,A Ali Khan,J Yin,TA Ferguson,RS Apte,J Kelly,A Ali Khan,J Yin,TA Ferguson,RS Apte,

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Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 3421-6

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 2

MONTH: Nov

YEAR: 2007

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. Information

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LANGUAGE: eng

NlmUniqueID: 7802877

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Grant and Affiliation Information for Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice.

AFFILIATION: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Country: United States

AGENCY: United States NEI

GRANT: K08EY016139

ACRONYM: EY

MEDLINETA: J Clin Invest

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