Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Abstract Text:

T A Colella,T N Bullock,L B Russell,D W Mullins,W W Overwijk,C J Luckey,R A Pierce,N P Restifo,V H Engelhard,

The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in melanocytes. To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived homologue of this peptide FMDGTMSQV, together with transgenic mice expressing the HLA-A*0201 recombinant molecule AAD. The murine peptide was processed and presented by AAD similarly to its human counterpart. After immunization with recombinant vaccinia virus encoding murine tyrosinase, we detected a robust AAD-restricted cytotoxic T lymphocyte (CTL) response to FMDGTMSQV in AAD transgenic mice in which the entire tyrosinase gene had been deleted by a radiation-induced mutation. A residual response was observed in the AAD(+)tyrosinase(+) mice after activation under certain conditions. At least some of these residual CTLs in AAD(+)tyrosinase(+) mice were of high avidity and induced vitiligo upon adoptive transfer into AAD(+)tyrosinase(+) hosts. Collectively, these data suggest that FMDGTMSQV is naturally processed and presented in vivo, and that this presentation leads to substantial but incomplete self-tolerance. The relevance of this model to an understanding of the human immune response to tyrosinase is discussed.

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Publishing Authors By Initials

TA Colella,TN Bullock,LB Russell,DW Mullins,WW Overwijk,CJ Luckey,RA Pierce,NP Restifo,VH Engelhard,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research

PUBMED ID PMID:

MEDLINE DATE:

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of experimental medicine

VOLUME: 191

Page Numbers: 1221-32

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 3

MONTH: Apr

YEAR: 2000

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Cytotoxic

MESH TERMS: immunology

Chemical & Substance for Abstract: Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. Information

Substance Name: Monophenol Monooxygenase

Registry Number: EC 1.14.18.1

Grant and Affiliation Information for Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.

AFFILIATION: Department of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: Z01 BC010763-01

ACRONYM: BC

MEDLINETA: J Exp Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy Related Publications

• Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.
• Atrioventricular block in a toxic child: do not forget diphtheria.
• Candida albicans infection in a child.
• Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes.
• Dendritic cell immunization route determines integrin expression and lymphoid and nonlymphoid tissue distribution of CD8 T cells.
• Empiric Treatment With Once-daily Cefonicid and Gentamicin for Febrile Non-neutropenic Pediatric Cancer Patients With Indwelling Central Venous Catheters.
• Immunity to melanoma antigens: from self-tolerance to immunotherapy.
• Incomplete differentiation of antigen-specific CD8 T cells in tumor-draining lymph nodes.
• Neuroimaging for the anesthesiologist.
• Paper-tape occlusion of anthralin paste. A new outpatient therapy for psoriasis.
• Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263.
• Processing of a class I-restricted epitope from tyrosinase requires peptide N-glycanase and the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic proteases.
• Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
• Semisynthesis of H-Ras with a glutamic acid methylester at position 61.
• Strategies and challenges in eliciting immunity to melanoma.
• Subcutaneous pneumatocele after facial trauma.
• [Results of the marketing research study "Acceptance of physician's office computer systems"]