Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment.

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Research Abstract Details 

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Abstract Text:

Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco,Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco,

The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive. We show that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendothelial cells within a miniature bone organ. Establishment of subendothelial stromal cells in developing heterotopic BM in vivo occurs via specific, dynamic interactions with developing sinusoids. Subendothelial stromal cells residing on the sinusoidal wall are major producers of Angiopoietin-1 (a pivotal molecule of the HSC "niche" involved in vascular remodeling). Our data reveal the functional relationships between establishment of the HME in vivo, establishment of skeletal progenitors in BM sinusoids, and angiogenesis.

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Publishing Authors By Initials

B Sacchetti,A Funari,S Michienzi,S Di Cesare,S Piersanti,I Saggio,E Tagliafico,S Ferrari,PG Robey,M Riminucci,P Bianco,B Sacchetti,A Funari,S Michienzi,S Di Cesare,S Piersanti,I Saggio,E Tagliafico,S Ferrari,PG Robey,M Riminucci,P Bianco,

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 131

Page Numbers: 324-36

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 19

MONTH: Oct

YEAR: 2007

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Information

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LANGUAGE: eng

NlmUniqueID: 413066

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Grant and Affiliation Information for Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment.

AFFILIATION: Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy.

Country: United States

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MEDLINETA: Cell

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