Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate.

Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Research Abstract Details 

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Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Abstract Text:

Seon-Joo Yoon,Shoko Ikeda,Martin Sadilek,Sen-itiroh Hakomori,Hideharu Ishida,Makoto Kiso,

Aminoceramide mimetic was synthesized and conjugated to N-linked oligosaccharides having multivalent GlcNAc by reductive amination. Ceramide mimetic conjugates with "complex-type" glycan having five or six GlcNAc termini (termed Os Fr. B-Cer) were purified, analyzed by thin-layer chromatography (TLC), and finally characterized by MS/MS analysis through liquid chromatography/mass spectrometry. Binding of Os Fr. B-Cer placed on solid phase polystyrene surface with [3H]cholesterol-labeled liposomes containing Os Fr. B-Cer, or containing various glycosphingolipids (GSLs) was determined. The binding of Os Fr. B-Cer liposomes to Os Fr. B-Cer coated plate was significantly higher than binding of GM3 liposomes. Other GSL liposomes showed no binding. Thus, self-recognition of Os Fr. B-Cer was clearly demonstrated using ceramide mimetic conjugates.

Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Publishing Authors By Initials

SJ Yoon,S Ikeda,M Sadilek,SI Hakomori,H Ishida,M Kiso,

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Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Glycobiology

VOLUME: 17

Page Numbers: 1007-14

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 2

MONTH: 07

YEAR: 2007

Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9104124

Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Keywords Mesh Terms:

KEYWORDS: Spectrometry, Mass, Electrospray Ionizat

MESH TERMS: chemistry

Chemical & Substance for Abstract: Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate. Information

Substance Name: Acetylglucosamine

Registry Number: 7512-17-6

Grant and Affiliation Information for Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate.

AFFILIATION: Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98195, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM070593

ACRONYM: GM

MEDLINETA: Glycobiology

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