Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Abstract Text:

Jun Panee,Zoia R Stoytcheva,Wanyu Liu,Marla J Berry,

Selenoprotein H is a recently identified member of the selenoprotein family whose function is not fully known. Previous studies from our laboratory and others showed that Drosophila melanogaster selenoprotein H is essential for viability and antioxidant defense. In this study we investigated the function of human selenoprotein H in murine hippocampal HT22 cells engineered to stably overexpress the protein. After treatment of cells with L-buthionine-(S,R)-sulfoximine to deplete glutathione, selenoprotein H-overexpressing cells exhibited higher levels of total glutathione, total antioxidant capacities, and glutathione peroxidase enzymatic activity than did vector control cells. Overexpression of selenoprotein H also up-regulated the mRNA levels of endogenous selenoprotein H, glutamylcysteine synthetase heavy and light chains, and glutathione S-transferases Alpha 2, Alpha 4, and Omega 1. The amino acid sequence of selenoprotein H contains four putative nuclear localization sequences and an AT-hook motif, a small DNA-binding domain first identified in high mobility group proteins. Chromatin immunoprecipitation using a green fluorescent protein-selenoprotein H fusion revealed binding to sequences containing heat shock and/or stress response elements. Thus, selenoprotein H is a redox-responsive DNA-binding protein of the AT-hook family and functions in regulating expression levels of genes involved in de novo glutathione synthesis and phase II detoxification in response to redox status.

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Publishing Authors By Initials

J Panee,ZR Stoytcheva,W Liu,MJ Berry,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 23759-65

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 25

MONTH: 05

YEAR: 2007

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

Chemical & Substance for Abstract: Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. Information

Substance Name: Glutathione

Registry Number: 70-18-8

Grant and Affiliation Information for Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.

AFFILIATION: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01-NS40302

ACRONYM: NS

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification Related Publications

• A role for dietary selenium and selenoproteins in allergic airway inflammation.
• Aerodynamically and acoustically driven modes of vibration in a physical model of the vocal folds.
• Associations among body condition score, body weight, and reproductive performance in seasonal-calving dairy cattle.
• Body Composition as a Predictor of Exercise Performance in COPD Patients: 1986: Board #56 May 31 2:00 PM 3:30 PM.
• Building and validating a prognostic index for biomarker studies.
• Cemented total knee arthroplasty using a modern prosthesis in young patients with osteoarthritis.
• Coherent structures of the near field flow in a self-oscillating physical model of the vocal folds.
• Commentary: the hazards of survival comparisons.
• Concentrate supplementation reduces postprandial plasma ghrelin in grazing dairy cows: a possible neuroendocrine basis for reduced pasture intake in supplemented cows.
• Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state.
• Detection and prediction of periodic patterns by the retina.
• Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.
• Electronic Self-report Assessment--Cancer (ESRA-C): Working towards an integrated survey system.
• Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.
• Improving drug treatment services for Hispanics: research gaps and scientific opportunities.
• Life's hard ... (sigh). A great bundle of big things.
• Patient reported activity after revision total knee arthroplasty.
• Relationships among body condition score, body weight, and milk production variables in pasture-based dairy cows.
• Revision total knee arthroplasty with modular cemented stems: long-term follow-up.
• Role of eye movements in the retinal code for a size discrimination task.
• Selectivity for multiple stimulus features in retinal ganglion cells.
• Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.
• Short communication: genetic selection for milk production increases plasma ghrelin in dairy cows.
• The absence of sadness: darker reflections on the doctor-patient relationship.
• The effects of acculturation on asthma burden in a community sample of Mexican American schoolchildren.
• The pain of residents with terminal cancer in USA nursing homes: family members' perspectives.
• The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.
• The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.
• Validation of a dissolution method with HPLC analysis for lasofoxifene tartrate low dose tablets.
• Visualization and quantification of the medial surface dynamics of an excised human vocal fold during phonation.