Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not.

Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Research Abstract Details 

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Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Abstract Text:

Raymond F Burk,Kristina E Hill,Akihiro Nakayama,Volker Mostert,Ximena A Levander,Amy K Motley,Delinda A Johnson,Jeffrey A Johnson,Michael L Freeman,Lori M Austin,

Selenium (Se) and vitamin E are antioxidant micronutrients. Se functions through selenoproteins and vitamin E reacts with oxidizing molecules in membranes. The relationship of these micronutrients with the Nrf2-antioxidant response element (ARE) pathway was investigated using ARE-reporter mice and Nrf2(-/-) mice. Weanling males were fed Se-deficient (0 Se), vitamin E-deficient (0 E), or control diet for 16 or 22 weeks. The ARE reporter was elevated 450-fold in 0 Se liver but was not elevated in 0 E liver. Antioxidant enzymes induced by Nrf2-ARE (glutathione S-transferase (GST), NAD(P)H quinone oxidoreductase (NQOR), and heme oxygenase-1 (HO-1)) were elevated in 0 Se livers but not in 0 E livers. Deletion of Nrf2 had varying effects on the inductions, with GST induction being abolished by it but induction of NQOR and HO-1 still occurring. Thus, Se deficiency, but not vitamin E deficiency, induces a number of enzymes that protect against oxidative stress and modify xenobiotic metabolism through Nrf2-ARE and other stress-response pathways. We conclude that Se deficiency causes cytosolic oxidative stress but that vitamin E deficiency does not. This suggests that the oxidant defense mechanisms in which these antioxidant nutrients function are independent of one another.

Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Publishing Authors By Initials

RF Burk,KE Hill,A Nakayama,V Mostert,XA Levander,AK Motley,DA Johnson,JA Johnson,ML Freeman,LM Austin,

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Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Free radical biology & medicine

VOLUME: 44

Page Numbers: 1617-23

Journal Abbreviation: Free Radic. Biol. Med.

ISSN: 0891-5849

DAY: 31

MONTH: 01

YEAR: 2008

Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not.

AFFILIATION: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-0252, USA.

Country: United States

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MEDLINETA: Free Radic Biol Med

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