[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants]

[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants] Research Abstract Details 

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[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants] Abstract Text:

Jin Zhang,Zhan-hui Wang,Jin-lin Hou,Hong Yang,Ai-lin Cheng,Xiu-hui Li,

OBJECTIVE: To investigate the role of hepatitis B virus (HBV) DNA levels in HBV-carrier mother and selective transmission of HBV variant with S gene mutation to infant in the failure of neonatal HBV immunization. METHODS: Serum HBV DNA level was determined by Roche LightCycler quantities in 95 HBsAg-positive pregnant women and later in their newborns. Hepatitis B virus S gene sequences isolated from mother/child pairs were analyzed in 7 cases which did not respond to HBV vaccination and hepatitis B immunoglobulin. RESULTS: HBV infection was identified in 7.4 % of the infants during their first year after birth. The levels of HBV DNA in the mothers of the infected infants were higher than those of the uninfected group, and selective transmission of HBV variant from mother to infant was observed. CONCLUSION: HBV DNA levels in HBV-carrier mother and selective transmission of HBV variant from mother to infant contribute to the failure of neonatal HBV immunization.

[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants] Publishing Authors By Initials

J Zhang,ZH Wang,JL Hou,H Yang,AL Cheng,XH Li,

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[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Di 1 jun yi da xue xue bao = Academic journal of t

VOLUME: 22

Page Numbers: 806-7, 810

Journal Abbreviation: Di Yi Jun Yi Da Xue Xue Bao

ISSN: 1000-2588

DAY: 25

MONTH: Sep

YEAR: 2002

[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants] Information

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LANGUAGE: chi

NlmUniqueID: 9426110

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Grant and Affiliation Information for [Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants]

AFFILIATION: Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

Country: China

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MEDLINETA: Di Yi Jun Yi Da Xue Xue Bao

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