Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping.

Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Research Abstract Details 

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Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Abstract Text:

Vitaliy Marchenko,Robert F Rogers,

Respiratory motor outputs contain medium-(MFO) and high-frequency oscillations (HFO) that are much faster than the fundamental breathing rhythm. However, the associated changes in power spectral characteristics of the major respiratory outputs in unanesthetized animals during the transition from normal eupneic breathing to hypoxic gasping have not been well characterized. Experiments were performed on nine unanesthetized, chemo- and barodenervated, decerebrate adult rats, in which asphyxia elicited hyperpnea, followed by apnea and gasping. A gated fast Fourier transform (FFT) analysis and a novel time-frequency representation (TFR) analysis were developed and applied to whole phrenic and to medial branch hypoglossal nerve recordings. Our results revealed one MFO and one HFO peak in the phrenic output during eupnea, where HFO was prominent in the first two-thirds of the burst and MFO was prominent in the latter two-thirds of the burst. The hypoglossal activity contained broadband power distribution with several distinct peaks. During gasping, two high-amplitude MFO peaks were present in phrenic activity, and this state was characterized by a conspicuous loss in HFO power. Hypoglossal activity showed a significant reduction in power and a shift in its distribution toward lower frequencies during gasping. TFR analysis of phrenic activity revealed the increasing importance of an initial low-frequency "start-up" burst that grew in relative intensity as hypoxic conditions persisted. Significant changes in MFO and HFO rhythm generation during the transition from eupnea to gasping presumably reflect a reconfiguration of the respiratory network and/or alterations in signal processing by the circuitry associated with the two motor pools.

Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Publishing Authors By Initials

V Marchenko,RF Rogers,

For similar circulatory and respiratory physiology: respiratory physiology: respiratory physiologic processes: respiration: respiratory mechanics research abstracts see: circulatory and respiratory physiology: respiratory physiology: respiratory physiologic processes: respiration: respiratory mechanics research

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Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 291

Page Numbers: R1414-29

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 6

MONTH: 07

YEAR: 2006

Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Keywords Mesh Terms:

KEYWORDS: Respiratory Mechanics

MESH TERMS: physiology

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Grant and Affiliation Information for Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping.

AFFILIATION: Dept. of Electrical and Computer Engineering, Univ. of Delaware, Newark, DE 19716, USA

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL68143

ACRONYM: HL

MEDLINETA: Am J Physiol Regul Integr Comp

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