Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp.

Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp. Research Abstract Details 

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Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp. Abstract Text:

Osamu Nakagawa,Sayaka Ono,Akira Tsujimoto,Zhichun Li,Shigeki Sasaki,Osamu Nakagawa,Sayaka Ono,Akira Tsujimoto,Zhichun Li,Shigeki Sasaki,Osamu Nakagawa,Sayaka Ono,Akira Tsujimoto,Zhichun Li,Shigeki Sasaki,Osamu Nakagawa,Sayaka Ono,Akira Tsujimoto,Zhichun Li,Shigeki Sasaki,

8-oxoguanosine, which is derived from the oxidation of guanosine (dG), is known to induce transversion mutations (G:CT:A) in DNA. The compounds with a small molecular weight for recognizing 8-oxoG were designed on the basis of the structure of the G-clamp, which is reported to have selective affinity toward guanosine. The G-clamp derivatives with the additional binding units toward 8-oxoG were effectively synthesized and named "8-oxoG-clamps." The 8-oxoG-clamp completely discriminated 8-oxoG from other nucleosides by fluorescence quenching.

Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp. Publishing Authors By Initials

O Nakagawa,S Ono,A Tsujimoto,Z Li,S Sasaki,O Nakagawa,S Ono,A Tsujimoto,Z Li,S Sasaki,O Nakagawa,S Ono,A Tsujimoto,Z Li,S Sasaki,O Nakagawa,S Ono,A Tsujimoto,Z Li,S Sasaki,

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Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleosides, nucleotides & nucleic acids

VOLUME: 26

Page Numbers: 645-9

Journal Abbreviation: Nucleosides Nucleotides Nuclei

ISSN: 1525-7770

DAY: 10

MONTH: 12

YEAR: 2007

Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Selective fluorescence detection of 8-oxoguanosine with 8-oxog-clamp.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Country: United States

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MEDLINETA: Nucleosides Nucleotides Nuclei

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