Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease.

Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Research Abstract Details 

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Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Abstract Text:

James A Olzmann,Jill R Bordelon,E Chris Muly,Howard D Rees,Allan I Levey,Lian Li,Lih-Shen Chin,

Mutations in DJ-1 cause autosomal recessive, early-onset Parkinson's disease (PD). The precise function and distribution of DJ-1 in the central nervous system remain unclear. In this study, we performed a comprehensive analysis of DJ-1 expression in human, monkey, and rat brains with antibodies that recognize distinct, evolutionarily conserved epitopes of DJ-1. We found that DJ-1 displays region-specific neuronal and glial labeling in human and nonhuman primate brain, sharply contrasting with the primarily neuronal expression pattern observed throughout rat brain. Further immunohistochemical analysis of DJ-1 expression in human and nonhuman primate brains showed that DJ-1 protein is expressed in neurons within the substantia nigra pars compacta and striatum, two regions critically involved in PD pathogenesis. Moreover, immunoelectron microscopic analysis revealed a selective enrichment of DJ-1 within primate striatal axons, presynaptic terminals, and dendritic spines with respect to the DJ-1 expression in prefrontal cortex. Together, these findings indicate neuronal and synaptic expression of DJ-1 in primate subcortical brain regions and suggest a physiological role for DJ-1 in the survival and/or function of nigral-striatal neurons.

Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Publishing Authors By Initials

JA Olzmann,JR Bordelon,EC Muly,HD Rees,AI Levey,L Li,LS Chin,

For similar nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: substantia nigra research abstracts see: nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: substantia nigra research

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Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of comparative neurology

VOLUME: 500

Page Numbers: 585-99

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 20

MONTH: Jan

YEAR: 2007

Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 406041

Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Substantia Nigra

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. Information

Substance Name: PARK7 protein, human

Registry Number: 0

Grant and Affiliation Information for Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease.

AFFILIATION: Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00165

ACRONYM: RR

MEDLINETA: J Comp Neurol

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