Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Research Abstract Details 

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Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Abstract Text:

Albana Gattelli, Zimberlin,Roberto P Meiss,Lucio H Castilla,Edith C Kordon,

Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral insertion upstream of the gene Rspo3, which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7. This study suggests that during progression towards hormone independence, clonal expansion of cells with specific mutations might be more relevant than the occurrence of new MMTV insertions.

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Publishing Authors By Initials

A Gattelli,MN Zimberlin,RP Meiss,LH Castilla,EC Kordon,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 80

Page Numbers: 11409-15

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 13

MONTH: 09

YEAR: 2006

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: virology

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Grant and Affiliation Information for Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.

AFFILIATION: IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, UBA Ciudad Universitaria, Pabellón 2, 2do piso, (1428) Buenos Aires, Argentina.

Country: United States

AGENCY: United States FIC

GRANT: R01TW006212

ACRONYM: TW

MEDLINETA: J Virol

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