Secretion of testicular steroids and gonadotrophins in hypothyroidism.

Secretion of testicular steroids and gonadotrophins in hypothyroidism. Research Abstract Details 

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Secretion of testicular steroids and gonadotrophins in hypothyroidism. Abstract Text:

A Kumar,B P Mohanty,L Rani,A Kumar,B P Mohanty,L Rani,A Kumar,B P Mohanty,L Rani,

Inconsistent alterations in gonadal steroidogenesis and pituitary functions have been reported in hypothyroid males. We have compared the lipid and endocrine profiles of the euthyroid and hypothyroid [thyroid-stimulating hormone (TSH) >100 mIU l(-1)] males. Hypothyroidism was found to be associated with an increase in the circulating level of total cholesterol and LDL-cholesterol (LDL-C) and a reduction in the levels of progesterone and testosterone, without any change in the serum levels of oestradiol and gonadotrophins. The failure of gonadotrophins to rise could be accounted by a normal level of serum oestradiol in the hypothyroid male. A mild hyperprolactinaemia was also noted in the hypothyroid patients. The reduction in serum testosterone level could be explained by (i) a reduced uptake of LDL-C by the Leydig cells and thereby a reduction in the synthesis of progesterone and consequentially testosterone, (ii) a further reduction in the rate of conversion of progesterone to testosterone, (iii) a higher rate of conversion of testosterone to oestradiol, (iv) a decrease in serum triiodothyronine and (v) hyperprolactinaemia. Rise in TSH needs to be investigated as a cause of the suppression of gonadal steroidogenesis.

Secretion of testicular steroids and gonadotrophins in hypothyroidism. Publishing Authors By Initials

A Kumar,BP Mohanty,L Rani,A Kumar,BP Mohanty,L Rani,A Kumar,BP Mohanty,L Rani,

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Secretion of testicular steroids and gonadotrophins in hypothyroidism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Andrologia

VOLUME: 39

Page Numbers: 253-60

Journal Abbreviation: Andrologia

ISSN: 0303-4569

DAY: 13

MONTH: Dec

YEAR: 2007

Secretion of testicular steroids and gonadotrophins in hypothyroidism. Information

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LANGUAGE: eng

NlmUniqueID: 423506

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Grant and Affiliation Information for Secretion of testicular steroids and gonadotrophins in hypothyroidism.

AFFILIATION: Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.

Country: Germany

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MEDLINETA: Andrologia

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