Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma.

Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Research Abstract Details 

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Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Abstract Text:

Meike ,Gregory M Hayes,Ruth Rehmann,Arthur Zimmermann,Arne Scholz,Bertram Wiedenmann,Laurence J Miller,Jean Claude Reubi,

BACKGROUND/AIMS: Gut hormone receptors are over-expressed in human cancer and allow receptor-targeted tumor imaging and therapy. A novel promising receptor for these purposes is the secretin receptor. The secretin receptor expression was investigated in the human liver because the liver is a physiological secretin target and because novel diagnostic and treatment modalities are needed for liver cancer. METHODS: Nineteen normal livers, 10 cirrhotic livers, 35 cholangiocarcinomas, and 45 hepatocellular carcinomas were investigated for secretin receptor expression by in vitro receptor autoradiography using (125)I-[Tyr(10)] rat secretin and, in selected cases, for secretin receptor mRNA by RT-PCR. RESULTS: Secretin receptors were present in normal bile ducts and ductules, but not in hepatocytes. A significant receptor up-regulation was observed in ductular reaction in liver cirrhosis. Twenty-two (63%) cholangiocarcinomas were positive for secretin receptors, while hepatocellular carcinomas were negative. RT-PCR revealed wild-type receptor mRNA in the non-neoplastic liver, wild-type and spliced variant receptor mRNAs in cholangiocarcinomas found receptor positive in autoradiography experiments, and no receptor transcripts in autoradiographically negative cholangiocarcinomas. CONCLUSIONS: The expression of secretin receptors in the biliary tract is the molecular basis of the secretin-induced bicarbonate-rich choleresis in man. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma.

Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Publishing Authors By Initials

M ,GM Hayes,R Rehmann,A Zimmermann,A Scholz,B Wiedenmann,LJ Miller,JC Reubi,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: gastrointestinal hormones: secretin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: gastrointestinal hormones: secretin research

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Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of hepatology

VOLUME: 45

Page Numbers: 825-35

Journal Abbreviation: J. Hepatol.

ISSN: 0168-8278

DAY: 28

MONTH: 07

YEAR: 2006

Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8503886

Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS: Secretin

MESH TERMS: genetics

Chemical & Substance for Abstract: Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. Information

Substance Name: Secretin

Registry Number: 1393-25-5

Grant and Affiliation Information for Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma.

AFFILIATION: Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, CH-3010 Bern, Switzerland.

Country: England

AGENCY: United States NIDDK

GRANT: DK46577

ACRONYM: DK

MEDLINETA: J Hepatol

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