Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries.

Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Research Abstract Details 

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Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Abstract Text:

Ghislaine ,Paolo Boffetta,Marilys Corbex,Kee-Seng Chia,Kari Hemminki,Soren Friis,Eero Pukkala,Elisabete Weiderpass,Mary L McBride,Elizabeth Tracey,David H Brewster,Vera Pompe-Kirn,Erich V Kliewer,Jon M Tonita,Carmen Martos,Jon G Jonasson,Paul Brennan,

OBJECTIVE: To study the risk of second primary cancers in nasopharyngeal carcinoma (NPC) patients and the risk of NPC as second primary cancer. METHODS: We used data from the cancer registries from Singapore and from 12 low-incidence areas, including a total of 8,947 first occurring NPC cases, and 167 second occurring cases. We calculated standardized incidence ratios (SIRs) by comparing the second cancer incidence in NPC patients to the first primary cancer incidence in non-cancer population. We also calculated SIRs of second NPC after other primaries. RESULTS: In Singapore, the risk of cancers of the lung (SIR=0.42), stomach (SIR=0.41), and colon (SIR=0.23) was significantly decreased after NPC, whereas that of cancer of the tongue (SIR=11.1) was significantly increased. In Australia, Canada, and Europe, the risk of non-Hodgkin's lymphoma (NHL) (SIR=3.06), tongue cancer (SIR=5.29), brain cancer (SIR=3.89), myeloid leukemia (SIR=3.85), and non-melanoma skin cancer (NMSC) (SIR=3.47) was significantly increased after NPC. Incidences of second occurring NPCs following various primary cancers were not significantly altered compared to the incidence of first occurring NPCs. CONCLUSIONS: Immune suppression (NHL, NMSC), shared genetic factors (lung cancer, NHL, myeloid leukemia), and shared environmental risk factors (tongue and brain cancers) might explain the associations. Except for NHL, there was no evidence of association with other Epstein-Barr virus-related cancers.

Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Publishing Authors By Initials

G ,P Boffetta,M Corbex,KS Chia,K Hemminki,S Friis,E Pukkala,E Weiderpass,ML McBride,E Tracey,DH Brewster,V Pompe-Kirn,EV Kliewer,JM Tonita,C Martos,JG Jonasson,P Brennan,

For similar geographic locations: asia: asia, southeastern: singapore research abstracts see: geographic locations: asia: asia, southeastern: singapore research

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MEDLINE DATE:

Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer causes & control : CCC

VOLUME: 18

Page Numbers: 269-78

Journal Abbreviation: Cancer Causes Control

ISSN: 0957-5243

DAY: 19

MONTH: 01

YEAR: 2007

Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Information

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LANGUAGE: eng

NlmUniqueID: 9100846

Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries. Keywords Mesh Terms:

KEYWORDS: Singapore

MESH TERMS: epidemiology

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Grant and Affiliation Information for Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries.

AFFILIATION: International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, 69008, France.

Country: Netherlands

AGENCY: United States NCI

GRANT: R03 CA101442-02

ACRONYM: CA

MEDLINETA: Cancer Causes Control

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