[Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation]

[Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation] Research Abstract Details 

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Dong-lin Yang,Ming-zhe Han,Si-zhou Feng,Mei Wang,De-hui Zou,Jia-lin Wei,Zhang-song Yan,Si-yong Zhou,Qing-guo Liu,Er-lie Jiang,Yong Huang,He-hua Wang,Zheng Zhou,Wen-jing Zhai,Wen-wei Yan,Zhong-chao Han,

OBJECTIVE: To evaluate the efficacy of second allogeneic hematopoietic stem cell transplantation (allo-HSCT) for treatment of leukemia relapsed after first allo-HSCT. METHODS: Nine patients with relapsed acute leukemia (5 AML, 4 ALL) and one with chronic myelogenous leukemia (CML) who showed cytogenetic relapse after first allo-HSCT received second allo-HSCT. The median relapse time from the first allo-HSCT was 141 days. Conditioning regimens for second allo-HSCT were combination chemotherapy based on moderate-dose Ara-C (n = 5), Bu (n = 3), conventional-dose Ara-C (n = 1) and Flud/Mel (n = 1). Prophylaxis for acute graft-versus-host disease (aGVHD) were CsA alone (n = 2), CsA/MTX (n = 1), FK506 (n = 1), and no prophylaxis in 6. The median number of peripheral blood mononuclear cells transfused was 6.1 x 10(8)/kg. RESULTS: Eight cases were evaluable. All of them were engrafted and 7 developed aGVHD (grade I 4, grade II 3). The median time for absolute neutrophil count (ANC) > 0.5 x 10(9)/L and platelets > 20 x 10(9)/L were 11 and 12 days, respectively. Five cases developed localized chronic GVHD. Of all the 10 cases received second allo-HSCT, 8 died from interstitial pneumonia (n = 2), multiple-organ failure (n = 1), sepsis (n = 1), fungous pneumonia (n = 1), and leukemia relapse (n = 3), and 2 survived without leukemia for +986 and +1913 days, respectively. The leukemia free survival, transplantation related mortality and relapse rate at 2 year were 20%, 50% and 30%, respectively. CONCLUSION: Second allo-HSCT is a therapeutic alternative for selected patients with relapsed leukemia after first allo-HSCT.

[Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation] Publishing Authors By Initials

DL Yang,MZ Han,SZ Feng,M Wang,DH Zou,JL Wei,ZS Yan,SY Zhou,QG Liu,EL Jiang,Y Huang,HH Wang,Z Zhou,WJ Zhai,WW Yan,ZC Han,

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[Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 285-9

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 8

MONTH: May

YEAR: 2004

[Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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