Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature.

Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Research Abstract Details 

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Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Abstract Text:

Yan-Hong Gu,Tadaaki Kato,Shohei Harada,Hiroaki Inomata,Tomohiro Saito,Kikumaro Aoki,

OBJECTIVE: Seasonality in the incidence of congenital hypothyroidism (CH) has been reported in several countries. The objective of this study was to examine whether seasonality was also observable in Japan and whether this seasonality affected genders differently. METHODS: Confirmed primary CH cases (n = 1586) occurring between 1994 and 2003 were examined through a retrospective review of the nationwide follow-up system at the Aiiku Maternal and Child Health Center, Tokyo, Japan. The number of live births in Japan was obtained from the country's vital statistics. Monthly incidence of CH was analyzed using time series analysis. The relationship between monthly incidence and ambient temperature was also investigated. MAIN OUTCOME: The sex ratio (female/male) was 1.25 for CH, against a background ratio of 0.95 for overall live births in Japan. Monthly CH incidence showed an upward time trend and clear seasonality among both males and females, but with different patterns between the two genders: from January to December, males had one peak while females had two peaks, which continued for a longer period than males had. A significant statistical correlation was found between the incidence and temperature (p < 0.001). CONCLUSION: In Japan, the monthly incidence of primary CH cases exhibits temperature-associated seasonality, gender-specific patterns, and an upward time trend.

Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Publishing Authors By Initials

YH Gu,T Kato,S Harada,H Inomata,T Saito,K Aoki,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Thyroid : official journal of the American Thyroid

VOLUME: 17

Page Numbers: 869-74

Journal Abbreviation: Thyroid

ISSN: 1050-7256

DAY: 19

MONTH: Sep

YEAR: 2007

Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Information

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LANGUAGE: eng

NlmUniqueID: 9104317

Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: epidemiology

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Grant and Affiliation Information for Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature.

AFFILIATION: Department of Health Policy, National Research Institute for Child Health and Development, Tokyo, Japan. gyh@nch.go.jp

Country: United States

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MEDLINETA: Thyroid

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