Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay.

Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay. Research Abstract Details 

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Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay. Abstract Text:

Shinobu Sato,Keiichi Ohtsuka,Shigeori Takenaka,

Interaction of ferrocenylnaphthalene diimide 1 with the tetraplex oligonucleotide, AGGG(TTAGGG)3, which is a part of human telomere sequence, was studied in 0.1 M AcONa-AcOH (pH 5.5) containing 0.1 M NaCl coupled with 22-meric single and double stranded oligonucleotides using spectrophotometric titration experiment to search for the more suitable tetraplex DNA-binding ligand to achieve the electrochemical telomerase assay. CD spectra and polyacrylamide gel electrophoresis revealed that this tetraplex oligonucleotide kept to the single conformational structure of basket type G-quadruplex under these conditions. Scatchard analysis showed that 1 can bind to the tetraplex oligonucleotide with the binding constant of 10(5) M(-1) order, which was the highest value among the other oligonucleotides. Binding number of 1 for these oligonucleotides were ca. 2, 11, and 3 for tetraplex, double stranded, and single stranded oligonucleotides, respectively. These values were reasonable when considering with the binding mode of 1 as a threading intercalator.

Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay. Publishing Authors By Initials

S Sato,K Ohtsuka,S Takenaka,

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Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids symposium series (2004)

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Page Numbers: 85-6

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Searching study for the suitable ferrocenylnaphthalene diimide derivative in the electrochemical telomerase assay.

AFFILIATION: Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, 680-4 Kawazu, Iizuka-shi, Fukuoka, 820-8502, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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