SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation.

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Abstract Text:

Endothelial progenitor cells (EPCs) have been shown to contribute to experimentally induced choroidal neovascularisation (CNV) in animal models. The recruitment pathway for EPCs is dependent on the chemokine stromal cell derived factor 1-alpha (SDF) and its receptor CXCR4 on the progenitor cell. We examined 23 specimens of CNV occurring secondary to a variety of aetiologies (10 secondary to age-related macular degeneration (AMD), 4 inflammatory, 4 idiopathic and 5 melanoma-associated) for the presence and distribution of SDF and CXCR4 in order to determine if this pathway may play a role in neovascularisation. Specimens were examined by immunohistochemistry using a panel of antibodies against SDF, CXCR4, vascular endothelial growth factor receptor 2 (VEGFR-2), CD34 (endothelial cells), CD68 (macrophages) and cytokeratins (retinal pigment epithelium; RPE). SDF was detected in 2 cases of CNV in AMD, 1 inflammatory CNV, 3 idiopathic CNVs and in 3 cases of CNV associated with melanoma. A significant association was found between SDF and VEGFR-2 immunostaining in individual membranes (p<0.001). Localisation of SDF immunostaining to the presumed RPE was also significant (p<0.05). CXCR4 immunostaining was widespread in all membranes in keeping with the published work of other investigators. Our study suggests that SDF, which may be produced by the RPE, could play a role in CNV.

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Microvascular research

VOLUME: 75

Page Numbers: 302-7

Journal Abbreviation: Microvasc. Res.

ISSN: 0026-2862

DAY: 23

MONTH: 12

YEAR: 2007

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 165035

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation.

AFFILIATION: Unit of Ophthalmology, Department of Clinical Sciences, UCD, Duncan Building, University of Liverpool, Daulby Street, Liverpool, L69 3GA, United Kingdom; Program in Stem Cell Biology, University of Florida, Gainesville, Florida 32610, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Microvasc Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation Related Publications

• Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
• Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response.
• Cytokeratin subtyping to distinguish reactive and neoplastic RPE cells.
• Health services in four isolated districts in Nova Scotia.
• Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin).
• Human papillomavirus in pterygium.
• Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
• Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.
• RIG-I has guts: identification of a role for RIG-I in colitis development.
• SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation.
• Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.
• Temporal pterygium: benign or not?
• Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates.
• Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.