Sculpting the proteome with AAA(+) proteases and disassembly machines.

Sculpting the proteome with AAA(+) proteases and disassembly machines. Research Abstract Details 

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Sculpting the proteome with AAA(+) proteases and disassembly machines. Abstract Text:

Robert T Sauer,Daniel N Bolon,Briana M Burton,Randall E Burton,Julia M Flynn,Robert A Grant,Greg L Hersch,Shilpa A Joshi,Jon A Kenniston,Igor Levchenko,Saskia B Neher,Elizabeth S C Oakes,Samia M Siddiqui,David A Wah,Tania A Baker,

Machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA(+) ATPase family-function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Exciting progress has been made in understanding how AAA(+) machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.

Sculpting the proteome with AAA(+) proteases and disassembly machines. Publishing Authors By Initials

RT Sauer,DN Bolon,BM Burton,RE Burton,JM Flynn,RA Grant,GL Hersch,SA Joshi,JA Kenniston,I Levchenko,SB Neher,ES Oakes,SM Siddiqui,DA Wah,TA Baker,

For similar proteins: proteome research abstracts see: proteins: proteome research

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Sculpting the proteome with AAA(+) proteases and disassembly machines. Journal Published:

PUBLICATION TYPE: Review

Journal: Cell

VOLUME: 119

Page Numbers: 9-18

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 1

MONTH: Oct

YEAR: 2004

Sculpting the proteome with AAA(+) proteases and disassembly machines. Information

Number of References: 77

LANGUAGE: eng

NlmUniqueID: 413066

Sculpting the proteome with AAA(+) proteases and disassembly machines. Keywords Mesh Terms:

KEYWORDS: Proteome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sculpting the proteome with AAA(+) proteases and disassembly machines. Information

Substance Name: Adenosine Triphosphatases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Sculpting the proteome with AAA(+) proteases and disassembly machines.

AFFILIATION: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM049224-12

ACRONYM: GM

MEDLINETA: Cell

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