Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Research Abstract Details 

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Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Abstract Text:

S Peter Bak,Julie Jo Walters,Motohiro Takeya,Jose R Conejo-Garcia,Brent L Berwin,

Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These leukocytes are converted by the tumor microenvironment to become tolerogenic, facilitate metastasis, and to aid in neovascularization. The predominant variety of suppressive leukocytes found in human and murine ovarian cancer are called vascular leukocytes (VLC), due to sharing functions and cell surface markers of both dendritic cells and endothelial cells. Using the ID8 murine model of ovarian cancer, the aim of this study was to test the efficacy of VLC elimination as an ovarian tumor therapy. We show that carrageenan-mediated depletion of peritoneal tumor-associated leukocytes inhibits ovarian tumor progression. We then identified scavenger receptor-A (SR-A) as a cell surface receptor that is robustly and specifically expressed within human and murine ovarian tumor ascites upon VLCs. Administration of anti-SR-A immunotoxin to mice challenged with peritoneal ID8 tumors eliminated tumor-associated VLCs and, importantly, substantially inhibited peritoneal tumor burden and ascites accumulation. Moreover, the toxin required targeting to SR-A because mice that received untargeted toxin did not exhibit inhibition of tumor progression. We conclude that SR-A constitutes a novel and specific target for efficacious immunotherapeutic treatment of peritoneal ovarian cancer.

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Publishing Authors By Initials

SP Bak,JJ Walters,M Takeya,JR Conejo-Garcia,BL Berwin,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, scavenger: scavenger receptors, class a research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, scavenger: scavenger receptors, class a research

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Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 4783-9

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: May

YEAR: 2007

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Keywords Mesh Terms:

KEYWORDS: Scavenger Receptors, Class A

MESH TERMS: immunology

Chemical & Substance for Abstract: Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Information

Substance Name: Carrageenan

Registry Number: 9000-07-1

Grant and Affiliation Information for Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.

AFFILIATION: Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI067405

ACRONYM: AI

MEDLINETA: Cancer Res

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