Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients.

Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Research Abstract Details 

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Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Abstract Text:

Nathan M Segerson,Sheldon E Litwin,Marcos Daccarett,T Scott Wall,Mohamed H Hamdan,Robert L Lux,

BACKGROUND: Increased spatial and temporal dispersion of repolarization contributes to ventricular arrhythmogenesis. Beat-to-beat fluctuations in T-wave timing are thought to represent such dispersion and may predict clinical events. OBJECTIVE: The purpose of this study was to assess whether a novel noninvasive measure of beat-to-beat instability in T-wave timing would provide additive prognostic information in post-myocardial infarction patients. METHODS: We studied 678 patients from 12 hospitals with 32-lead 5-minute electrocardiogram recordings 6-8 weeks after myocardial infarction. Custom software identified R wave-to-T wave intervals (RTIs) and diastolic intervals (DIs). Repolarization scatter (RTI:DI(StdErr)) was then calculated as the standard error about the RTI:DI regression line. In addition, left ventricular ejection fraction (LVEF), short-term heart rate variability (HRV) parameters, and QT variability index were measured. Patients were followed for the composite endpoint of death or life-threatening ventricular arrhythmia. RESULTS: After a mean follow-up of 63 months, 134 patients met the composite endpoint. An RTI:DI(StdErr) >5.50 ms was associated with a 210% increase in arrhythmias or deaths (P <.001). After adjusting for LVEF, RTI:DI(StdErr) remained an independent predictor (P <.001). RTI:DI(StdErr) was also independent of short-term HRV parameters and the QT variability index. CONCLUSIONS: Increased repolarization scatter, a measure of high-frequency, cycle-length-dependent repolarization instability, predicts poor outcomes in patients after myocardial infarction.

Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Publishing Authors By Initials

NM Segerson,SE Litwin,M Daccarett,TS Wall,MH Hamdan,RL Lux,

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Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Heart rhythm : the official journal of the Heart R

VOLUME: 5

Page Numbers: 208-14

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ISSN: 1547-5271

DAY: 6

MONTH: 10

YEAR: 2007

Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Information

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LANGUAGE: eng

NlmUniqueID: 101200317

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AFFILIATION: University of Utah School of Medicine, Department of Internal Medicine, Division of Cardiology, Salt Lake City, Utah.

Country: United States

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MEDLINETA: Heart Rhythm

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